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“We investigated the effectiveness of the beta-blocking agent metipranolol in preventing detrimental systemic and myocardial alterations induced in healthy dogs by adrenaline (AD) infused at a rate which mimics spontaneous secretion after coronary occlusion.”
“8 The studies demonstrate that by an unknown mechanism β‐adrenoceptor blockade with (±)‐propranolol , either alone or in combination with phenoxybenzamine, lowers the plasma adrenaline response evoked by adrenaline infusion.”