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“Compared with the control group, MB reduced the requirement for norepinephrine, epinephrine , and dopamine by as much as 87%, 81%, and 40%, respectively.”
“The pressor effect of adrenaline injected into the splenic vein is much increased by the simultaneous injection of methylene blue , and Philpot and Cantonil concluded that the amine oxidase in the liver is inhibited by such treatment.”
“This conclusion is borne out by the observation that the potentiating effect of methylene blue on the pressor response to adrenaline is much weaker when given by the jugular route than when given directly into the portal system.”
The Journal of pharmacy and pharmacology • 1951 | View Paper
“Compared with epinephrine alone, the methylene blue–epinephrine association avoided neuronal excitotoxicity and had an additive effect both on hemodynamic variables and for prevention of brain ischemia.”