Possible Interaction: Epinephrine and Methoxyflurane

“6 We conclude that the volatile anaesthetics ethrane, halothane, isoflurane and methoxyflurane inhibit the secretion of adrenaline and noradrenaline induced by carbachol at concentrations that lie within the range encountered during general anaesthesia.”

“ Methoxyflurane increases the rate of phase 4 depolarization and potentiates the action of epinephrine.”

“The arrhythmias provoked by an epinephrine challenge during methoxyflurane anaesthesia were less severe than those seen in similar experiments with trichlorethylene, cyclopropane, and halothane, but were similar, to those during anaesthesia with halothane-ether azeotrope and light chloroform.”

“…;epinephrine … methoxyflurane , unless a small amount is injected sub-cutaneously in a very dilute solution ( less than 1:200,000 )RésuméAprès 25 minutes d’anesthésie avec … arythmies cardiaques produites par l’administration d’épinéphrine et, en même temps, le degré de protection procurée par le SA 97 (un antihistaminique ).”