Possible Interaction: Epinephrine and Methoxamine

“Variations in myocardial function and systemic resistance were induced by the administration of epinephrine and methoxamine.”

“Only ephedrine and methoxamine were found to be capable of reversing the epinephrine depressor effect to a pressor effect.”

“Although epinephrine was associated with significantly higher blood pressures than placebo during cardiopulmonary resuscitation (CPR), blood pressures achieved with methoxamine were significantly higher than those observed in the other three treatment groups (p less than .001).”

“ Methoxamine , but not clonidine, was able to mimic the effect of epinephrine.”

“ Adrenaline enhances the response of Purkinje fibres, depressed by exposure to high K+ concentration5 and we now report that an α-adrenergic agent, methoxamine , depresses the slow response at concentrations that do not affect the normal action potential.”

“The partial suppression of diazoxide hyperglycemia by adrenalectomy and BW 61–43 isopropyl methoxamine ), a specific inhibitor of the metabolic effects of epinephrine , suggests that the metabolic effects of diazoxide are mediated, at least in part, by adrenergic hormones.”

“ Methoxamine effectively inhibited the activation of phosphorylase activity by epinephrine in diaphragm, liver and heart.”

“The cardiac action of large doses of methoxamine and its antagonistic action to epinephrine were studied, using a dog heart-lung preparation.”