Possible Interaction: Epinephrine and Methionine

“Combinations of epinephrine with methionine enkephalin or morphine increased the binding of both by about half a log unit.”

“Incubation of cultured fetal adrenal cells with PACAP38 ( 10−7 M ) significantly increased cortisol and DHEAS secretion.”

“It had a mean reversal potential of +45 mV. The Ba2+ inward current was diminished when adrenaline or isoprenaline was added to the bath (1 × 10−5 M ); however, this decrease did not occur when propranolol was present (5 × 10−6 M).”

“Maximal secretion occurred during stimulation using 10−7 M and 10−8 M Ep with a suppression of release at supramaximal concentrations.”

“Since the M current is suppressed by adrenaline in the parasympathetic ganglia and these ganglia often receive adrenergic fibres from sympathetic ganglia, this might reflect an important means of interaction between the two branches of the autonomic system.”

“Treatment of the intact retina with docosahexaenoic acid in … range 0.5 × 10‐6‐l × 10‐ M does not affect the enzyme activity measured in the absence of the hormone but markedly … the cyclase activity when the tissue is incubated in the presence of 0.1 mM epineph‐rine.”

“During the first 10 min following stimulation by 10−6 M epinephrine , the total cell calcium, 45Ca and the mitochondrial calcium were significantly depressed in male hepatocytes.”

“In doses ranging from 10−8–10−5 M , the substances produced a parallel shift in the dose-response curve for adrenaline.”

“In addition, our results showed that local injections of Epi at doses greater than 10-8 M produced an extreme drop in intrapulpal pressure (IPP).”