Possible Interaction: Epinephrine and Mepivacaine

“Both mepivacaine and bupivacaine added to the adrenaline solution increased the plasma concentration of adrenaline.”

“the decrease in B‐Hb was twice as great for those who developed hypotension during the onset of the blockade as for patients whose arterial pressure remained normal (P<0.001), both when epidural anaesthesia was induced with plain mepivacaine, and when mepivacaine plus adrenaline was used.”

“and paracervical blockade with 2 x 10 ml of mepivacaine 20 mg/ml + adrenaline 0.005 mg/ml.”

“Inferior alveolar nerve block was induced using 2.8 mL 2% mepivacaine with epinephrine.”

“Both the temporal relationship of events and the response to treatment suggest that a rapid systemic absorption of mepivacaine with adrenaline and/or interaction of these drugs with the patient's cardiovascular medications were responsible for the perioperative complications.”

“Thus, the T1‐L2 epidural anaesthesia with 2% mepivacaine with adrenaline blocked the blood pressure reaction to laryngoscopy and intubation, and consequently the efferent sympathetic nervous system was completely blocked.”

“The mean analgesic levels obtained using 2% mepivacaine with epinephrine were C4-T8 in the cervical group, and T7-S1 in the lumbar group.”

“ Epinephrine significantly lowered the concentrations of lidocaine in the mothers' circulations by about 33 per cent, and the concentrations of mepivacaine by about 22 per cent.”

“The duration of action of mepivacaine hydrochloride makes the undesirable use of epinephrine or of cumbersome techniques for continuous administration of the anesthetic solution unnecessary.”

“D H U N ~ R ( 1964)4 and D … N ~ R , HARTHON, HERBRINC and LIE (1965) found that epinephrine had a marked effect … blood concentration of mepivacaine when used for hernia repair or injected subcutaneously, but little effect … intramuscularly and virtually no effect when used for brachial plexus block.”