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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Meperidine
Research Papers that Mention the Interaction
“No change in hemodynamics was noted, but a significant increase in plasma norepinephrine and epinephrine levels (from 0.9 to 1.6 nmol/L and from 0.3 to 0.8 nmol/L, respectively; p < 0.05) was observed after meperidine administration.”
Effects of tramadol and meperidine on respiration, plasma catecholamine concentrations, and hemodynamics.“There was a trend towards lower mean total consumption of pethidine in the adrenaline group (231.5 mg; SD 140.5 mg) compared with the plain group (289.5 mg; SD 139.5 mg; p = 0.071).”
“The median duration of analgesia was longer in the adrenaline group (196 min; IQR 123–286) … with the plain group (96 min; IQR 43–113; p = 0.002) and plasma concentrations of pethidine in the first 30 min after injection were lower in the adrenaline group (p = 0.003).”
“We conclude that coadministration of epinephrine or clonidine with meperidine enhances the duration and degree of spinal anesthesia and that adding clonidine prolongs the duration of postoperative analgesia. (”
“Conclusions: Addition of meperidine or fentanyl to lidocaine and epinephrine solution increases the duration of postoperative analgesia in cesarean section.”
Addition of Intrathecal Fentanyl or Meperidine to Lidocaine and Epinephrine for Spinal Anesthesia in Elective Cesarean Delivery
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