Possible Interaction: Epinephrine and Melatonin

“ Epinephrine preworkout elevation may offset early morning melatonin concentrations to maintain maximal muscular force and power in track athletes.”

“The colocalization of MT1 and CRH suggests that melatonin might directly modulate the hypothalamus–pituitary– adrenal axis in the PVN, which may have implications for stress conditions such as depression.”

“There is a relationship between adrenal androgens and melatonin in these women.”

“ Nonadrenalin stimulates melatonin synthesis through cAMP accumulation.”

“In the present study, we found that melatonin has a marked inhibitory effect on collagen, arachidonic acid (AA), adenosine diphosphate (ADP), epinephrine , and A23187‐induced aggregation in platelet‐rich plasma.”

“In addition, we investigated how epinephrine regulates the synthesis of melatonin and the transcription of the key melatonin synthesis enzyme AANAT.”

“These results demonstrate for the first time that epinephrine can increase the synthesis of melatonin by increasing the transcription of AANAT.”

“Conflicting evidence for a regulatory role of melatonin on adrenal cortisol production, prompted us to investigate this possibility in a New World primate, the capuchin monkey.”

“Intravenous infusion of 1 or 2 ng melatonin resulted in a decrease, and 10 or 20 ng or larger amount of melatonin caused an increase in the efferent activity of the adrenal nerve.”

“Neither PX nor melatonin replacement changed corticosterone output by adrenal homogenate, 11 beta-hydroxylase activity, liver corticosterone metabolism or serum corticosterone level, however, melatonin increased adrenal 5 alpha-reductase activity.”

“This phenomenon can be explained by amplification of sympathetic pressor activity by stress hormones, adrenaline , corticosterone and prolactin, under the influence of melatonin.”