Possible Interaction: Epinephrine and Leucine

“The combined … of epinephrine resulted in higher V(d/f) (197.86 vs. 140.… L for (+)-(R) and 169.46 vs. 132.81 L for (-)-(S)) and t(1/2)beta values (4.36 vs. 3.24 h for (+)-(R) and 4.45 vs. 3.30 h for (-)-(S)).”

“ Leucine and ketoisocaproate (KIC) fluxes were 2.3±0.2 and 2.6±0.2 μmol/kg/min, respectively, at baseline and gradually decreased to 1.8±0.2 and 2.2±0.1 μmol/kg/min, respectively, after 240 min of adrenaline infusion (bothp<0.05).”

“Plasma leucine concentrations decreased by 28% (p<0.05) from baseline during epinephrine treatment (plasma levels 515 pg/ml); this was due to a decrease of leucine appearance (determined by 1-13C-leucine infusions) by 23% (p<0.025); leucine oxidation decreased by 29% (p<0.05).”

“Infusion of epinephrine (plasma concentration: approximately 3600 pmol/L) decreased leucine and phenylalanine and increased ketoisocaproate plasma concentrations and increased the metabolic clearance rate of leucine and phenylalanine.”

“Net forearm release of leucine increased during epinephrine (P less than 0.01), suggesting increased muscle proteolysis; the fall of total body leucine flux was therefore due to diminished proteolysis in nonmuscle tissues, such as splanchnic organs.”

“… leucine concentrations decreased … during epinephrine infusion by 27 +/- 5 mumol/liter (P less than 0.02) due to a 22 +/- 6% decrease in leucine flux (P less … 0.05 vs. controls receiving saline) and to an increase in the metabolic clearance rate of leucine (P less than 0.02).”

“Although leucine nitrogen Ra increased transiently and returned to basal values, leucine carbon Ra and Rd decreased (P less than 0.05) during the infusion of epinephrine.”

“Infusion of epinephrine in humans increases glucose production and decreases plasma concentrations of some essential amino acids such as leucine , while not affecting the plasma concentration of the potential gluconeogenic amino acid alanine.”

“When adrenaline was added to the incubation medium at the start of the pulse, the incorporation of [3H]leucine was markedly reduced, suggesting that the rate of the enzyme's synthesis had decreased.”

“ Epinephrine (10-4 m) stimulated 14CO2 production from leucine , valine, and alanine by hemidiaphragms of fasted rats incubated without substrate, but not by hemidiaphragms of rats fed ad libitum.”