Possible Interaction: Epinephrine and Ketanserin

“ Ketanserin , a selective 5-HT2 serotonergic receptor antagonist, reducesin vitro the release-associated human platelet aggregation induced by threshold concentrations of collagen and curtails the second wave of aggregation/release induced by critical concentrations of ADP in particular and, to a lesser extent, of 1-epinephrine.”

“ Ketanserin , a 5HT2 receptor antagonist completely blocked the response of 5-HT plus epinephrine and this in the nanomolar concentration range in which the drug selectively antagonizes 5-HT2 receptor-mediated responses.”

“In vitro as well as in vivo ketanserin exerts a concentration-dependent inhibitory effect on the active transport of serotonin and catecholamines (dopamine, noradrenaline, adrenaline ) into human platelets.”

“ Ketanserin , a serotonin (5-hydroxytryptamine2) receptor antagonist, abolished epinephrine-restored CFVs and eliminated CFVs in dogs in which CFVs had not been eliminated by free radical scavengers.”

“ Ketanserin markedly inhibits in vitro platelet aggregation induced by mixing serotonin and epinephrine.”

“In a dose range where it produces hypotension ketanserin antagonized the pressor responses to adrenaline and noradrenaline as well as to 5‐hydroxytryptamine in monoamine depleted and spinalized rats.”