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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Ketanserin
Research Papers that Mention the Interaction
“ Ketanserin , a selective 5-HT2 serotonergic receptor antagonist, reducesin vitro the release-associated human platelet aggregation induced by threshold concentrations of collagen and curtails the second wave of aggregation/release induced by critical concentrations of ADP in particular and, to a lesser extent, of 1-epinephrine.”
Effects of ketanserin, a selective 5-HT2 serotonergic antagonist, on the secondary recruitment of human plateletsin vitro“ Ketanserin , a 5HT2 receptor antagonist completely blocked the response of 5-HT plus epinephrine and this in the nanomolar concentration range in which the drug selectively antagonizes 5-HT2 receptor-mediated responses.”
“In vitro as well as in vivo ketanserin exerts a concentration-dependent inhibitory effect on the active transport of serotonin and catecholamines (dopamine, noradrenaline, adrenaline ) into human platelets.”
“ Ketanserin , a serotonin (5-hydroxytryptamine2) receptor antagonist, abolished epinephrine-restored CFVs and eliminated CFVs in dogs in which CFVs had not been eliminated by free radical scavengers.”
“ Ketanserin markedly inhibits in vitro platelet aggregation induced by mixing serotonin and epinephrine.”
“In a dose range where it produces hypotension ketanserin antagonized the pressor responses to adrenaline and noradrenaline as well as to 5‐hydroxytryptamine in monoamine depleted and spinalized rats.”
Cardiovascular effects in the rat of ketanserin, a novel 5‐hydroxytryptamine receptor blocking agent
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