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Last Updated: 2 years ago

Possible Interaction: Epinephrine and Ketamine

supplement:

Epinephrine

Research Papers that Mention the Interaction

During ketamine anesthesia, both epinephrine (15 ± 10 pg/ml to 256 ± 193 pg/ml) and norepinephrine (250 ± 105 pg/ml to 570 ± 270 pg/ml) plasma concentrations significantly increased, as did heart rate (67 ± 13 beats/min to 113 ± 15 beats/min).
Anesthesiology  •  2000  |  View Paper
Ketamine (500 &mgr;m) suppressed … (0.5 &mgr;m), epinephrine (1 &mgr;m), (+)-9,11-epithia-11,12-methano-TXA2 (STA2) (0.5 &mgr;m), and thrombin (0.02 U/… ± 30.9, 46.3 ± 4.3, −2.0 ± 16.8, and 86.6 ± 1.4% of zero-control, respectively.
Anesthesiology  •  2002  |  View Paper
Intravenous ketamine dissociation anesthesia combined with epinephrine solution infiltration may provoke serious tachyarrhythmias despite diazepam premedication and the use of minimal doses of both drugs.
Annals of plastic surgery  •  1985  |  View Paper
Ketamine alone did not produce motor block, but addition of adrenaline resulted in complete motor block, and may have intensified sensory blockade.
Anaesthesia  •  1984  |  View Paper
Adrenalin plays an important role in the control of duration of ketamine anesthesia, while noradrenalin, dopamine and corticosterone have no such function.
Medical hypotheses  •  2014  |  View Paper
A subthreshold dose … each isomer of ketamine (10(-4) mol litre-1) which alone did not relax histamine-induced contraction (…(+), P < 0.01; R(+/-), P < 0.01; R(-), P < 0.05) significantly potentiated adrenaline 1.25-5.0 x 10(-9) mol …-1-induced relaxation (potency: S(+) > R(+/-) > R(-)).
We conclude that although both ketamine isomers produced equipotent spasmolytic effects on airway smooth muscle precontracted with histamine, they differed in their ability to potentiate the relaxing effect of adrenaline.
British journal of anaesthesia  •  1996  |  View Paper
In chronically catheterized rats, diethyl ether, ketamine and urethane increased plasma adrenaline (A) and noradrenaline (NA) concentrations, indicating that these drugs stimulate both neurosympathetic and adrenomedullary functions.
European journal of pharmacology  •  1987  |  View Paper
Ketamine potentiated, whereas cocaine inhibited, responses to tyramine Experiments using the technique of oil immersion demonstrated that ketamine reduced the rate at which aortic strips inactivate adrenaline even when monoamine oxidase (MAO) and neuronal uptake processes were fully inhibited.
Uptake studies showed that ketamine and 17 beta-estradiol reduced extraneuronal accumulation of [3H]adrenaline in aortic strips.
Canadian journal of physiology and pharmacology  •  1981  |  View Paper
This action took place with ketamine concentrations found in anaesthetic plasma concentrations, i.e., 1 x 10(-5) to 2 x 10(-4) M.3 Ketamine (10(-5) to 10(-3) M) dose-dependently attenuated contractions induced by adrenaline , noradrenaline, angiotensin II, vasopressin and KCl.
British journal of pharmacology  •  1980  |  View Paper
Ketamine significantly increased brain epinephrine (25%), serotonin (28%) and 5-hydroxy indoleacetic acid (32%) in rats.
The increase in epinephrine (13%) and decrease in norepinephrine (31%) and dopamine (38%) levels remained significant 12 hours after ketamine injection.
Research communications in chemical pathology and pharmacology  •  1978  |  View Paper
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