Possible Interaction: Epinephrine and Kakonein

“The arteriole diameter (D) and blood flow velocity (V) of arterioles were observed and recorded by …, and blood flow (Q) was calculated as Q = pi (D/2)2.V. Results indicate that puerarin applied … adrenaline on arteriole, impeded the constriction and increased …, 20 minutes (P less than 0.01).”

“When puerarin and papaverin were given intravenously to mice at the dosages of 52 and 10 mg/kg respectively, both showed protective effects on the microcirculatory disturbance induced by adrenaline administered locally 5 min later.”