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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Epinephrine
drug:
Isosorbide Dinitrate
Research Papers that Mention the Interaction
“Plasma-renin activity, epinephrine , and norepinephrine were increased by ISDN substantially more than by ITF 296.”
Hemodynamic and Humoral Effects at Rest and After Head‐Up Tilt Tests During 24‐Hour Infusion of a New Nitrate Ester, ITF 296, Compared with ISDN and Placebo in Healthy Volunteers: A Double‐Blind, Randomized, Within‐Subject Study“Individuals responding to ISDN with more pronounced vasodilatation at rest showed a lesser increase in aggregability during the ensuing adrenaline infusion (r = -0.66, P = 0.02) despite higher adrenaline levels during ISDN.”
“It is concluded that ISDN may affect platelet aggregation responses to adrenaline in vivo, but only in individuals showing significant haemodynamic responses to ISDN.(ABSTRACT TRUNCATED AT 250 WORDS)”
“ ISDN , 2-ISMN and 5-ISMN (isosorbide nitrates, ISN) inhibited both ADP- and epinephrine (EPI)-induced platelet aggregation.”
Differential Inhibitory Effects of Isosorbide Dinitrate and its Mononitrate Metabolites on Platelet Aggregation and Thromboxane Formation
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