Possible Interaction: Epinephrine and Isoproterenol

“In summary, the use of isoproterenol as an adjuvant to epinephrine in asystolic patients may increase the likelihood of return of spontaneous circulation.”

“The effect of isoproterenol could be mimicked by epinephrine , theophylline, and (Bu)2-cAMP, indicating that elevated levels of cAMP are the common mechanism by which these agents affect PGE2 binding.”

“ Isoprenaline potentiated the contraction produced by adrenaline and reversed the adrenaline relaxation to a contraction.”

“Almost 60 years ago, the compound dichloroisoproterenol hydrochloride was found to inhibit the activities of epinephrine and is considered as the first "-blocker ("-adrenergicblocking agent).”

“ ISO also produced a dose-dependent increase in the mixed venous plasma concentrations of noradrenaline and 3,4-dihydroxyphenylglycol (DOPEG), and a decrease in that of adrenaline.”

“Acute sensitization of the lymphocytic &bgr;-adrenergic cascade was induced by the administration of epinephrine reflected by increased cAMP production after stimulation with isoproterenol and PGE1.”

“Importantly, epinephrine dose dependently inhibited PAI-1 parameters, an effect that was reproduced by isoproterenol.”

“ Isoproterenol infusion significantly shortened the P wave duration to 110 +/- 16 ms (p < 0.001), and epinephrine resulted in significant prolongation to 150 +/- 10 ms (p < 0.05).”

“ Isoprenaline and sodium nitroprusside increased and epinephrine decreased forearm norepinephrine spillover.”

“ANS, propranolol, dopamine and adrenaline caused concentration-dependent inhibition of isoprenaline binding to AAG with apparent dissociation constants of 5.1 +/- 1.8 microM, 6.4 +/- 1.1 microM, 0.57 +/- 0.13 mM and 1.5 +/- 0.46 mM, respectively.”