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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Isoflurane
Research Papers that Mention the Interaction
“Patients sedated with isoflurane showed a progressive reduction in both adrenaline and noradrenaline concentrations during the period of sedation which reached statistical significance for adrenaline at 6h (p<0.02) and at the end of the study (p<0.001).”
Plasma catecholamine concentration during sedation in ventilated patients requiring intensive therapy“During isoflurane anesthesia , an epinephrine-containing test dose produces unreliable heart rate (HR) responses with a high incidence of hypertension, whereas an isoproterenol-containing test dose results in a high incidence of hypotension.”
“In all groups, plasma epinephrine and norepinephrlne concentrations increased after administration of 2% and 1% Isoflurane , respectively.”
“ Epinephrine levels were lowered by isoflurane anesthesia.”
“Intramuscular epinephrine significantly reduces time to first movement during isoflurane anesthetic recovery in loggerhead sea turtles.”
INHALANT ANESTHETIC RECOVERY FOLLOWING INTRAMUSCULAR EPINEPHRINE IN THE LOGGERHEAD SEA TURTLE (CARETTA CARETTA)“Compared with fentanyl/fluanisone/midazolam anesthesia, isoflurane resulted in a shorter time to return of spontaneous circulation (ROSC), less use of epinephrine , increased coronary perfusion pressure during cardiopulmonary resusitation, higher mean arterial pressure post-ROSC, increased plasma levels of endothelin-1, and decreased levels of epinephrine.”
“Therefore, IM epinephrine administered at the end of general anesthesia can significantly hasten anesthetic recovery from isoflurane in alligators.”
“Background Halothane more so than isoflurane potentiates an &agr;1-adrenoceptor (&agr;1-AR)-mediated action of epinephrine that abnormally slows conduction in Purkinje fibers and may facilitate reentrant arrhythmias.”
“ Isoflurane administered before ischemia increased the arrhythmogenic dose of epinephrine (ADE), but had no effect on ADE when administered after reperfusion.”
“Without methylatropine, isoflurane and enflurane, but not halothane, further enhanced the baroreflex‐mediated negative chronotropic effects of epinephrine , whereas with methylatropine, each anesthetic reduced the direct positive chronotropic effects of epinephrine.”
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