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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Isoflurane

supplement:

Epinephrine

Research Papers that Mention the Interaction

Compared with fentanyl/fluanisone/midazolam anesthesia, isoflurane resulted in a shorter time to return of spontaneous circulation (ROSC), less use of epinephrine , increased coronary perfusion pressure during cardiopulmonary resusitation, higher mean arterial pressure post-ROSC, increased plasma levels of endothelin-1, and decreased levels of epinephrine.
Journal of applied physiology  •  2017  |  View Paper
Therefore, IM epinephrine administered at the end of general anesthesia can significantly hasten anesthetic recovery from isoflurane in alligators.
Journal of Zoo and Wildlife Medicine  •  2017  |  View Paper
BACKGROUND Halothane more so than isoflurane potentiates an alpha1-adrenoceptor (alpha1-AR)-mediated action of epinephrine that abnormally slows conduction in Purkinje fibers and may facilitate reentrant arrhythmias.
Anesthesiology  •  2000  |  View Paper
Isoflurane administered before ischemia increased the arrhythmogenic dose of epinephrine (ADE), but had no effect on ADE when administered after reperfusion.
Research communications in molecular pathology and pharmacology  •  1998  |  View Paper
Without methylatropine, isoflurane and enflurane, but not halothane, further enhanced the baroreflex-mediated negative chronotropic effects of epinephrine , whereas with methylatropine, each anesthetic reduced the direct positive chronotropic effects of epinephrine.
Anesthesiology  •  1995  |  View Paper
CONCLUSIONS It was concluded that isoflurane with E or NE acts synergistically to increase dysrhythmic potential in the arterial tissue.
Dysrhythmogenic potential of E and NE tended to be greater after earlier exposure to isoflurane.
Every combination of isoflurane with E or NE produced a significant increase in the incidence of pacemaker shifts and normalized shift scores.
Anesthesiology  •  1993  |  View Paper