Possible Interaction: Epinephrine and Insulin

“In addition ACTH and epinephrine were also lower after human insulin at 0.075 IU/kg.”

“ Epinephrine levels were also higher during insulin as compared to placebo infusion (249.8+/-17.4 vs. 212.8+/-21.1 pmol/l, p<0.001).”

“This finding supports the hypothesis that high insulin levels associated with PCOS may cause an increase in plasma levels of adrenal androgens.”

“Thus, the changes in plasma volume and composition in response to hypoglycaemia are due to the combined actions of adrenaline and of insulin.”

“Therefore, our data do not permit the conclusion that epinephrine suppresses insulin release exclusively by diminishing the rate of synthesis of cyclic AMP.”

“These results suggest that systemic epinephrine , perhaps by evoking central norepinephrine release, modulated the increase in the forebrain GABA(A) receptor recruitment induced by both insulin and stress in different ways depending on the subpopulation fearfulness.”

“Renal glucose release is stimulated by epinephrine and is inhibited by insulin.”

“glucose production by the human kidney is stimulated by epinephrine and inhibited by insulin.”

“Furthermore, insulin (10 nM) almost completely blocked the increase in cAMP levels induced by epinephrine in lean rat hepatocytes, whereas it only provoked a small and nonsignificant reduction of epinephrine-stimulated levels of the cyclic nucleotide in hepatocytes obtained from obese rats.”

“The presence of insulin in the incubation medium antagonized, in a concentration-dependent manner, the effects of epinephrine.”

“We observed in the HIT cell, a clonal insulin-secreting cell line, that epinephrine and somatostatin lower insulin mRNA levels and intracellular insulin content in addition to the well-recognized effect of these hormones to inhibit insulin secretion.”