Possible Interaction: Epinephrine and Insulin

“ Epinephrine levels were also higher during insulin as compared to placebo infusion (249.8+/-17.4 vs. 212.8+/-21.1 pmol/l, p<0.001).”

“Therefore, our data do not permit the conclusion that epinephrine suppresses insulin release exclusively by diminishing the rate of synthesis of cyclic AMP.”

“Studies show that the stress of trauma causes the release of hormones epinephrine and cortisol) that counter-regulate the normal action of insulin , thereby predisposing patients to hyperglycemia and ketoacidosis6.”

“ Epinephrine , a known platelet sensitizer and antagonist of insulin, abolishes the effect of insulin on [Ca(2+)](i), tyrosine phosphorylation of G(i)alpha(2), and aggregation by interfering with the phosphorylation of the insulin receptor beta subunit.”

“Instead, high insulin levels are able to restrict the ketogenic response to epinephrine in both normal and Type 1 diabetic subjects, although there is a still detectable lipolytic response in the latter.”

“ E and MN correlated significantly and inversely with dehydroepiandrosterone sulfate, estradiol, testosterone, leptin, and insulin.”

“These data suggest that insulin may modify the glycemic response to epinephrine in a potentially favorable direction and indicate some lag time before epinephrine gains effect.”

“ Epinephrine release was strongly correlated with the hemodynamic effects of insulin.”

“In both groups, insulin increased glucose uptake, glycogen synthesis, and whole body carbohydrate (CHO) oxidation and inhibited GP (by 70-80%) and lipid oxidation (by approximately 50%), whereas epinephrine antagonized the effect of insulin on glucose uptake and glycogen synthesis.”

“Plasma insulin concentration increased after repeated epinephrine treatment in both obese (14.3 +/- 0.6 to 18.2 +/- 1.6 microU/ml; P < 0.05) and lean (8.4 +/- 1.3 to 11.1 +/- 1.5 microU/ml; P < 0.01) subjects.”