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Possible Interaction: Epinephrine and Indomethacin

supplement:

Epinephrine

Research Papers that Mention the Interaction

epinephrine … indomethacin , a cyclo-oxygenase inhibitor, these results suggest that this reduction of intraocular pressure is at least partially mediated by the endogenous production of prostaglandins, … the intraocular pressure of glaucoma patients undergoing epinephrine therapy may increase when systemic cyclo-oxygenase inhibitors such as indomethacin or aspirin are taken.
American journal of ophthalmology  •  1985  |  View Paper
We hypothesized that the combination of indomethacin and topical spray of epinephrine on the duodenal papillae would further reduce PEP than when indomethacin was used alone.
The American journal of gastroenterology  •  2019  |  View Paper
Treatment with indomethacin , PP2, SB202190, and PD98059, respective inhibitors of COX enzymes, Src, p38MAPK, and ERK completely abrogated the effect of epinephrine.
PloS one  •  2018  |  View Paper
Subsequent perfusion studies showed that very large concentrations of indomethacin were necessary to block the outflow facility effect of epinephrine , suggesting that prostaglandin synthesis did not underlie the facility effect in this system.
Journal of ocular pharmacology  •  1994  |  View Paper
Indomethacin (1 microgram/ml), a cyclooxygenase inhibitor, remarkably inhibited epinephrine plus ADP induced serotonin release, 40K-dalton protein phosphorylation and DG production although this agent had little effect on the same reactions induced by thrombin.
Thrombosis research  •  1983  |  View Paper
Aspirin or indomethacin inhibited fibrinogen binding stimulated by 10 microM epinephrine by 53%, and inhibited fibrinogen binding stimulated by 1-2 microM ADP by 37.1%.
The Journal of clinical investigation  •  1981  |  View Paper
When indomethacin was used to inhibit cyclo-oxygenase activity, Ca2+ mobilization in response to epinephrine or U46619 was partially blocked, whereas Ca2+ release in response to A23187 was unaltered.
The American journal of physiology  •  1981  |  View Paper
Similarly, partial reversal of this alpha-adrenergic effect of Epi was observed with indomethacin , another inhibitor of PG synthesis.
The American journal of physiology  •  1980  |  View Paper
Indomethacin abolishes the effects of epinephrine on washed platelets.
Thrombosis research  •  1980  |  View Paper
4) PG synthesis inhibitors such as indomethacin or flurbiprofen block, or partially inhibit, the reduction of IOP produced by epinephrine , para-aminoclonidine, forskolin, vanadate, verapamil, arachidonic acid, and ALT in rabbits, cats, monkeys, and/or humans.
Progress in clinical and biological research  •  1989  |  View Paper
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