Possible Interaction: Epinephrine and Indomethacin

“… epinephrine … indomethacin , a cyclo-oxygenase inhibitor, these results suggest that this reduction of intraocular pressure is at least partially mediated by the endogenous production of prostaglandins, … the intraocular pressure of glaucoma patients undergoing epinephrine therapy may increase when systemic cyclo-oxygenase inhibitors such as indomethacin or aspirin are taken.”

“ Indomethacin significantly inhibited systemic prostaglandin biosynthesis as measured by urinary excretion (87 +/- 12 vs 41 +/- 6 ng PGE/g creatinine/h) and the drug increased platelet aggregation time two, five, and six fold, respectively, induced by ADP, collagen, and adrenaline.”

“Pretreatment with indomethacin significantly reduced albumin extravasation after the administration of adrenaline but not after bicuculline, i.e. when acute hypertension was combined with a metabolically mediated cerebral vasodilatation.”

“In human platelet‐rich plasma, p‐chlorobiphenyl and indomethacin prevented the secondary aggregation and blocked ATP release from platelets induced by adenosine 5′‐diphosphate and adrenaline without affecting the primary aggregation.”

“4) PG synthesis inhibitors such as indomethacin or flurbiprofen block, or partially inhibit, the reduction of IOP produced by epinephrine , para-aminoclonidine, forskolin, vanadate, verapamil, arachidonic acid, and ALT in rabbits, cats, monkeys, and/or humans.”

“Thus, both indomethacin and salicylate blunt the glycemic response to glucagon and glucagon plus epinephrine by attenuating glucose production and not by enhancing glucose utilization or insulin secretion.”

“We hypothesized that the combination of indomethacin and topical spray of epinephrine on the duodenal papillae would further reduce PEP than when indomethacin was used alone.”

“ Spray epinephrine should not be used with rectal indomethacin for prevention of post-ERCP pancreatitis.”

“Treatment with indomethacin , PP2, SB202190, and PD98059, respective inhibitors of COX enzymes, Src, p38MAPK, and ERK completely abrogated the effect of epinephrine.”

“Trifluoperazine (10(-6) g/mL) as the calmodulin antagonist, barium chloride (10(-…/mL) as a blocked of Ca(2+)-dependent K(+)-channels and indomethacine (10(-6) g/mL) as an inhibitor of … and phospholipase A2 inhibit the ability of adrenaline to increases the speed of … of red blood cells.”