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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Epinephrine
drug:
Indobufen
Research Papers that Mention the Interaction
“At low concentrations (10 microM), indobufen completely inhibited secondary platelet aggregation, the release reaction and TxB2 production stimulated by ADP, epinephrine and low concentrations of platelet-activating factor (PAF acether).”
In vitro and ex vivo effects of indobufen on human platelet aggregation, the release reaction and thromboxane B2 production.“When given to 12 subjects at single oral doses of 100 and 300 mg, indobufen caused clear-cut, dose-dependent, reversible inhibition of epinephrine- and collagen-induced platelet aggregation.”
“ Indobufen demonstrated antithrombotic activity in vivo in animals against the lethal thrombotic effects of epinephrine and collagen and prevented graft occlusion following vascular surgery.”
Indobufen : A review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy in Cerebral, Peripheral and Coronary Vascular Disease.
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