Possible Interaction: Epinephrine and Imipramine

“With imipramine there was potentiation of the pressor effects of phenylephrine (2-3 fold), noradrenaline (4-8 fold), and adrenaline (2-4 fold); there were dysrhythmias during adrenaline infusions, but no noticeable or consistent changes in response to isoprenaline.”

“Daily administration of adrenaline for further 6 days with IMI feeding in the chronically IMI treated rabbits, led to enhancement in the hyperglycemic response to adrenaline (P less than 0.001).”

“Simultaneous administration of insulin, oral glucose or adrenaline with single doses of IMI resulted in an enhancement of usual hypoglycemic/hyperglycemic responses of these agents.”

“Injection of imipramine induced a reduction of adrenaline concentration in the spleen and submaxillary gland.”

“ Imipramine and protriptyline blocked both the effects on epinephrine and norepinephrine, although higher doses were required to protect epinephrine.”

“Application of imipramine , which inhibits specifically the uptake of noradrenaline and adrenaline in different tissues, caused a rapid aggregation of the melanophores in black background-adapted animals.”

“Cocaine, imipramine and pipradol potentiated the contractions to adrenaline and noradrenaline, but not to tyramine, on the nictitating membrane of the spinal cat.”