Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Epinephrine and Idazoxan

supplement:

Epinephrine

Research Papers that Mention the Interaction

The inhibitory effects of epinephrine were prevented by the alpha 2-adrenergic antagonist idazoxan , but were unaffected by the alpha 1-adrenergic antagonist phenoxybenzamine.
Endocrinology  •  1991  |  View Paper
dose of idazoxan (300 micrograms kg-1) caused an immediate 2-fold increase in plasma concentration of norepinephrine and epinephrine , a transient increase in heart rate but no significant change in MAP.
The Journal of pharmacology and experimental therapeutics  •  1988  |  View Paper
After beta blockade, norepinephrine and epinephrine produced dose related increase of coronary perfusion pressure which was not remarkedly reduced by prazosin but significantly blunted after yohimbine or idazoxan.
Zhongguo yao li xue bao = Acta pharmacologica Sinica  •  1987  |  View Paper
In the presence of propranolol, antagonism of EPI by both prazosin and idazoxan was reduced in proximal segments, and the inhibitory effect of a reduction in calcium ion concentration was lost.
The antagonistic effect of idazoxan (100 nM) against EPI was greater in distal than in proximal segments, whereas the opposite result was obtained with prazosin (0.1-10 nM).
The Journal of pharmacology and experimental therapeutics  •  1987  |  View Paper
When alpha 2-adrenergic receptors were blocked by the addition of idazoxan (0.1 and 1 microM), epinephrine still raised [Ca2+]i.
Molecular pharmacology  •  1985  |  View Paper