Possible Interaction: Epinephrine and Idazoxan

“The inhibitory effect of idazoxan in vitro was confirmed; addition of idazoxan to platelet suspensions prior to adrenaline caused a competitive inhibition of the aggregatory response by specific antagonism of the platelet alpha 2-adrenoreceptor.”

“The infusion of adrenaline alone had no significant effect on insulin release while in the presence of idazoxan , insulin release was markedly stimulated by adrenaline.”

“After vehicle, adrenaline caused no change in plasma noradrenaline concentration whereas it rose approximately 25% after administration of idazoxan.”

“Chlorpromazine, amitriptyline and idazoxin inhibited larval metamorphosis induced by 10−4 M epinephrine.”

“The agonists, adrenaline and UK‐14304, were approximately 5 and 10 fold less potent against [3H]‐idazoxan and [3H]‐RX‐821002, respectively, than against [3H]‐clonidine.”

“The inhibitory effects of epinephrine were prevented by the alpha 2-adrenergic antagonist idazoxan , but were unaffected by the alpha 1-adrenergic antagonist phenoxybenzamine.”

“However, epinephrine only partially competed for the 3H-labeled UK 14304 and [3H]idazoxan , suggesting that these imidazolinic radioligands labeled not only alpha 2-adrenoceptors but also nonadrenergic binding sites.”

“ Adrenaline increased plasma IRI levels in the presence of idazoxan but not in the presence of either prazosin or propranolol.”

“Large differences were observed in the ability of noradrenaline, adrenaline , idazoxan, rauwolscine, yohimbine and WY 26392 to displace [3H]yohimbine and [3H]idazoxan from their binding sites.”

“The non-selective agonist, adrenaline , induces a similar hyperglycemic response which is antagonized selectivity by the alpha 2-adrenoceptor antagonist, idazoxan.”