Possible Interaction: Epinephrine and Hydrogen Peroxide

“In cultured renal podocytes, H2O2 production was substantially augmented by epinephrine (probably through &bgr;2-adrenergic receptors) and modestly diminished by norepinephrine (probably through &agr;1-adrenergic receptors).”

“Extracellular H2O2 induced significant damage to the DNA, but it had a smaller effect when applied with epinephrine.”

“Exposure … adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE … activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide , but not of either 2,4‐dinitirophenol or tunicamycin.”

“ Adrenaline and isoproterenol inhibited the production of hydrogen peroxide , stimulated the production of nitric oxide, and increased the extracellular activity of acid phosphatase in the lipoprotein-activated cells.”

“Agents known to increase the intracellular levels of cyclic AMP, e.g. adrenalin and PGE2 reduce the hydrogen peroxide production.”

“In contrast, epinephrine strongly potentiated superoxide anion production, while markedly inhibiting hydrogen peroxide production.”

“The procedure is suitable for use with a wide range of MAO substrates, although 5-hydroxytryptamine, adrenaline and noradrenaline are too readily oxidized by hydrogen peroxide to be used.”

“A peroxidatic dehydrogenation was demonstrated with epinephrine or guaiacol in the presence of various hydroperoxides , including hydrogen peroxide and prostaglandin G1.”

“ Adrenaline , adrenochrome and noradrenaline in low concentrations potentiate the inactivation of myosin by H2O2.”

“Soluble protein in seeds treated with epinephrine and H2O2 decreased significantly by 34% and 33% as compared to untreated seeds.”