supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Epinephrine
Research Papers that Mention the Interaction
“Concerning the size of peak area of anesthesia, epinephrine increased the area relative to lidocaine alone more than hyaluronidase (626 versus 221 mm2).”
“ Epinephrine delayed the time to reach peak area of anesthesia (onset) relative to lidocaine alone more than hyaluronidase (0.28 h versus 0.04 h).”
“This suggests a negative interaction (inhibition) because hyaluronidase decreased the epinephrine effect by 21 percent.”
The effects of hyaluronidase on local anesthesia: a prospective, randomized, controlled, double-blind study.“The mixture with adrenalin and hyaluronidase was significantly more effective than the other (success rates of 77.8% and 25.9%, p < 0.005).”
“Akinesia as produced by either the O'Brien or Van Lint method has been found to be more rapid, certain, and profound when hyaluronidase is added to the procaineepinephrine combination.”
Injection of hyaluronidase into the anterior chamber of the rabbit eye.“Propylene glycol produces slight shock and the resultant liberation of adrenalin probably is responsible for inhibition of hyaluronidase activity.”
Inhibition of Testicular Hyaluronidase Activity by Rutin.∗“The mechanism by which these and the other known vitamin P substances act … is unknown, although Lavollay (7) has postulated that they function as inhibitors of adrenalin oxidation, and that adrenalin itself or its first … true vitamin P. It has been suggested that hyaluronidase plays a role … capillary strength.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback