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Possible Interaction: Epinephrine and Histamine

supplement:

Epinephrine

Research Papers that Mention the Interaction

The provocative dose of histamine causing a 20% fall in FEV1 increased progressively with increasing concentrations of infused epinephrine , geometric mean values ranging from 0.61 mumol with placebo to 1.7 mumol after the highest dose of epinephrine.
Journal of applied physiology  •  1992  |  View Paper
Epinephrine caused a significant elevation in the concentration of histamine required to cause a 35% fall in specific airway conductance (PC35), although this was in part caused by a small airway dilator effect.
The Journal of allergy and clinical immunology  •  1984  |  View Paper
Platelet aggregation by epinephrine was completely inhibited at 10(-3) M concentrations of histamine.
American journal of hematology  •  1980  |  View Paper
Histamine is a powerful agent with many physiological actions, such as being an antagonist to epinephrine in dilating the arterioles and capillaries.
JAMA  •  1972  |  View Paper
A strong contraction was observed with both the patient's and a control cardiac muscle when bradykinin, serotonin and epinephrine were added to the bath, but these tissues seem to be relatively insensitive to the action of histamine.
The American journal of medicine  •  1967  |  View Paper
Hypothalamic electrical activities were observed as follows;1) The injection of epinephrine and histamine evoked increased electrical activity in the posterior hypothalamus.2) Electrical activity in the supraoptic region showed a transient increase and decrease with intracarotid injections of hypertonic NaCl solution and water respectively.
The Japanese journal of physiology  •  1955  |  View Paper
After receiving IN epinephrine , the histamine group had a significantly lower Tmax versus the saline group (6 vs 70 min, respectively; p = 0.02).
Respiratory Research  •  2020  |  View Paper
Background Adrenaline quickly inhibits the release of histamine from mast cells.
BioMed research international  •  2020  |  View Paper
Our findings point to the existence of a histamine-adrenal axis in which the release of histamine may facilitate the release of epinephrine which in turn may restrict further release of histamine.
Neurochemistry International  •  1985  |  View Paper
There is substantial old evidence that epinephrine and isoproterenol, in doses that depress the pentagastrin effect, actually augment that of histamine and cholinomimetics.
The Mount Sinai journal of medicine, New York  •  1989  |  View Paper
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