Modification of bronchial reactivity by physiological concentrations of plasma epinephrine.

 causing a 20% fall in FEV1 increased progressively with increasing concentrations of infused 

, geometric mean values ranging from 0.61 mumol with placebo to 1.7 mumol after the highest dose of epinephrine.

Protective effect of circulating epinephrine within the physiologic range on the airway response to inhaled histamine in nonasthmatic subjects.

 caused a significant elevation in the concentration of 

 required to cause a 35% fall in specific airway conductance (PC35), although this was in part caused by a small airway dilator effect.

α 1-Adrenergic Receptor Blockade by Prazosin Synergistically Stabilizes Rat Peritoneal Mast Cells

The role of sympathetic innervation and sympathomimetics in gastric secretion in vivo.

 and isoproterenol, in doses that depress the pentagastrin effect, actually augment that of 

Histamine and the antihistaminic drugs.

 by acting on effector cells in a direction opposite to that of histamine.

 or certain antihistaminic substances provokes the release of 

 and thereby produces a rise in the histamine blood level.

Reflections on the analytical pharmacology of histamine h2-receptor antagonists.

The parallels between the pharmacology of

A microcomputer system for assessment of peripheral blood flow. An example of nasal blood flow.

In the nasal blood flow iontophoretically administered

Systemic adrenaline attenuates skin response to antigen and histamine

 and both the flare and weal of antigen (P< 0.05).

Histamine uptake by human platelets.

Conventional platelet aggregating agents (e.g.

 uptake at sub-aggregatory concentrations.

Inhibition of platelet aggregation with histamine

 was completely inhibited at 10−3 M concentrations of 

Histamine explanation of acupuncture.

 is a powerful agent with many physiological actions, such as being an antagonist to 

 in dilating the arterioles and capillaries.

Penicillin hypersensitivity with eosinophilia; a case report with immunologic studies.

A strong contraction was observed with both the patient's and a control cardiac muscle when bradykinin, serotonin and

 were added to the bath, but these tissues seem to be relatively insensitive to the action of 

Hypothalamic electrical activities produced by factors causing discharge of pituitary hormones.

Hypothalamic electrical activities were observed as follows;1) The injection of

 evoked increased electrical activity in the posterior hypothalamus.2) Electrical activity in the supraoptic region showed a transient increase and decrease with intracarotid injections of hypertonic NaCl solution and water respectively.

An approach to the problem of "epinephrine fastness".

The experimental observations described lead us to conclude that repeated administrations of

 to such individuals produce an increase in plasma 

 overcoming the effects of the epinephrine.

Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.

 evokes the secretion of noradrenaline and 

 from adrenal medulla by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.

Adrenaline-stimulated, aspirin-sensitive synthesis of histamine in the rat

The intravenous injection of 40 μg/kg of

 from 5.3±0.7 μg, to 8.4±0.7 μg and rat skin histamine from 624±51 μg to 835±85 within 5 min.

Increase in plasma catecholamines by intraventricular injection of histamine in conscious rats

SummaryIntraventricular administration of

 (HA; 2.5 and 5 μg) caused a significant increase of 

 and noradrenaline levels in conscious freelymoving male rats.

Submucosal microinfusion of endothelin and adrenaline mobilizes ECL‐cell histamine in rat stomach, and causes mucosal damage: a microdialysis study

Submucosal microinfusion of endothelin or

, known to cause vasoconstriction and gastric lesions, mobilized striking amounts of 

Studies on the involvement of histamine in the hypothalamic-pituitary-adrenal axis activation induced by nerve growth factor.

Moreover, since mast cells are reportedly present … rat adrenal gland and the locally released

 which, in turn, stimulates glucocorticoid synthesis and secretion, we studied the effect of NGF on basal …-stimulated corticosterone release from in vitro isolated quartered adrenal glands and collagenase-dispersed adrenal cells.

Mechanisms of bradykinin-induced catecholamine release in pithed spontaneously hypertensive rats.

 dose-dependently increased catecholamine release whereby a marked preference for 

[Changes in parameters of the systemic hemodynamics during combined action of humoral stimuli exerting various effects on arterial pressure].

 caused a decrease in only the AP and TPR, whereas CO, HR and SV were increased.

Relaxant effect of ketamine and its isomers on histamine-induced contraction of tracheal smooth muscle.

We conclude that although both ketamine isomers produced equipotent spasmolytic effects on airway smooth muscle precontracted with

, they differed in their ability to potentiate the relaxing effect of 

Enhancement of airway reactivity to histamine by isoprenaline and related β‐adrenoceptor agonists in the guinea‐pig

5 Infusions of bronchodilator concentrations of

 and salbutamol also enhanced airway reactivity to 

, but the bronchodilator effect of salbutamol lasted longer than that of isoprenaline or adrenaline and the development of hyperreactivity was delayed.

Brain regulation of renin secretion involves central histaminergic neurons.

 as well as restraint stress increased the plasma levels of dopamine, norepinephrine and 

Histamine as a neuroendocrine regulator of the stress-induced release of peripheral catecholamines.

 (HA; 30 micrograms) increased the plasma concentrations of norepinephrine (NE) and 

Mechanism of histamine-induced epinephrine release in guinea pig.

 infusion caused a 3-fold rise in plasma 

Sensory fibres modulate histamine‐induced catecholamine secretion from the rat adrenal medulla and sympathetic nerves.

 and noradrenaline secretion by a non‐neurogenic mechanism.

On the mechanism of bronchodilatation by etafedrine.

Contraction of the tracheal chain by acetylcholine or

 (adrenaline), etafedrine and ephedrine, the relative potencies being 91:1:0.3, respectively.

Enhancement of histamine synthesis in mouse skin by epinephrine.

Intravenous administration of 10-40 micrograms/Kg

 to mice leads to a transient 50% increase in 

, followed by an increase in blood histamine.

Effect of histamine on adenosine 3',5'-cyclic monophosphate levels in granulation tissue.

 but partially blocked a similar effect of 

The influence of catecholamines and serotonin on histamine uptake and metabolism by guinea pig atrium.

, norepinephrine and serotonin were found to reduce the 

 uptake and the formation of methylhistamine, in a dose-dependent fashion.

A comparison of the inhibition of phosphodiesterase activity and allergic histamine release by disodium cromoglycate and compound I.C.I. 74917.

Compounds that increase cellular cyclic AMP concentrations, such as isoprenaline,

 and prostaglandin El, inhibit the release of 

 from sensitive tissues after antigen challenge (Assem & Schild, 1969; Lichtenstein & Margolis, 1968).

Vasoactive agents and the gastric microcirculation.

, serotonin, and compound 48 80 inhibited 

 induced vasoconstriction of small arterioles in the submucosa.

CHARACTERISTICS OF THE CATECHOLAMINE AND HISTAMINE RECEPTOR SITES MEDIATING ACCUMULATION OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN GUINEA PIG BRAIN 1

 together were far greater than the sum of effects of either hormone alone in both cerebral cortex and hippocampus.

Effect of histamine, bradykinin and morphine on adrenaline release from rat adrenal gland.

Technique for implanting lower airway catheters chronically in dogs, in order to expose and record pulmonary function.

, was effective in blocking the bronchoconstricting effects of intravenously administered 

Adrenergic Mechanisms in the Effects of Histamine in the Pulmonary Circulation of the Cat

 had increased PVR in adrenalectomized cats, 

 (5 μg iv) reduced PA-LA pressure and PVR.

Some biochemical factors that modify the transcephalic DC potential.

 produces either a positive or negative shift, and potentiates the effects of 

STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE.

, which suggests that the cell membrane was the site of action; in contrast to the stimulant action of histamine or acetylcholine, the effect … degrees C, and enhanced at 40 degrees C. The depressant action of anaesthetics on smooth muscle is affected very little by temperature changes.

The bronchoconstrictor action of bradykinin in the guinea-pig.

 and isoprenaline suppressed the bronchoconstrictor responses to bradykinin and 

Pressor effect of histamine in the rabbit.

By ganglionic blockade the pressor effect of histamine was enhanced and the antagonism between

 in a single small dose diminished and, given in a single higher dose or repeated small doses reversed, the pressor effect of histamine.

 diminished the epinephrine pressor effect but never reversed it.

The inhibiting effect of epinephrine and norepinephrine on secretion induced by histamine in separated pouches of dogs.

Continuous gastric secretion of separated pouches (Heidenhain type) in dogs in response to

 was inhibited by the continuous intravenous injection of either 

Influence of blood sampling conditions upon histamine concentrations in rat plasma: a study of a complex relationship with plasma epinephrine

Our findings point to the existence of a histamine-adrenal axis in which the release of

 which in turn may restrict further release of histamine.

Effect of hypothermia on histamine release induced by epinephrine infusion.

 infusion results in a considerable rise of 

Histamine release by adrenaline and d‐tubocurarine in the human subject

Staub (1946a, b) detected an increase in the plasma

 level of human subjects during intravenous infusions of 

, and suggested that some of the effects of the adrenaline could be attributed to the released histamine.

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Possible Interaction: Epinephrine and Histamine

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Research Papers that Mention the Interaction