Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Epinephrine and Hexamethonium

supplement:

Epinephrine

Research Papers that Mention the Interaction

In cats, rats and pigeons, concentrations of hexamethonium , tetra‐ethylammonium and pentolinium ions too low to influence transmission in autonomic ganglia potentiate the pressor effects of adrenaline , noradrenaline and of reflex vasoconstriction.
The Journal of pharmacy and pharmacology  •  1963  |  View Paper
Neither adrenalectomy nor adrenergic "blockade" prevented the positive inotropic response to hypoxia, and hexamethonium paradoxically sensitized the heart to epinephrine.
American heart journal  •  1957  |  View Paper
Endogenous acetylcholine (nerve stimulation)-induced epinephrine release was inhibited by hexamethonium but not atropine.
In either case, epinephrine release was inhibited by atropine as well as hexamethonium.
Autonomic Neuroscience  •  2003  |  View Paper
Second, pre-treatment with the nicotinic receptor antagonist hexamethonium inhibited the electrically evoked secretion of adrenaline and noradrenaline.
The Journal of experimental biology  •  1999  |  View Paper
Hexamethonium (10-100 microM) markedly inhibited the ES-induced increases in Epi and NE output from adrenal glands of SHRs and WKY rats.
The American journal of physiology  •  1999  |  View Paper
The adrenal NA and Adr responses to 10(3) microM ACh between 84 and 137 days were reduced by up to 99% after the addition of hexamethonium.
Experimental physiology  •  1995  |  View Paper
Hexamethonium markedly reduced the ANS response to insulin injection ( ΔEPI + 2130 ± 600 pM, P < 0.025 vs. control) despite a similar fall of plasma glucose (Δ −4.1 ± 0.2 mM) and a lower nadir (0.6 ± 0.1 mM).
Diabetes  •  1991  |  View Paper
Blockade of neural input to the adrenal by hexamethonium (25 mg/kg) reduced but did not eliminate the increases in plasma norepinephrine and epinephrine concentrations in fetuses at 109-119 days gestation, while it completely abolished these responses in fetuses at 130-136 days gestation.
The American journal of physiology  •  1990  |  View Paper
Hexamethonium decreased in a dose-dependent manner the elevations in plasma adrenaline , corticosterone and glucose levels that were elicited by the 5-HT1A receptor agonist, 8-OH-DPAT (0.25 mg/kg).
European journal of pharmacology  •  1990  |  View Paper
The enhancement of PFC by epinephrine was completely blocked by preadministration with propranolol and hexamethonium , but not with phentolamine.
Journal of immunology  •  1987  |  View Paper
Show More