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Possible Interaction: Epinephrine and Heparin

supplement:

Epinephrine

drug:

Heparin

Research Papers that Mention the Interaction

RESULTS Lipid emulsion + heparin infusion was associated with a rise in plasma epinephrine and norepinephrine concentrations.
The American journal of clinical nutrition  •  2000  |  View Paper
These results show that EPI contributes significantly to the anticoagulant effect of heparin in human blood.
Haemostasis  •  1991  |  View Paper
Heparin was found to increase slightly ADP and epinephrine induced aggregation and to decrease cAMP.
Arzneimittel-Forschung  •  1987  |  View Paper
Heparin potentiates the first aggregation step induced by ADP and epinephrine but inhibits aggregation induced by thrombin and ristocetin.
Folia haematologica  •  1984  |  View Paper
Heparin potentiates the aggregating effect of adenosine diphosphate (ADP) and epinephrine , but it is uneffective on the aggregation induced by ristocetin and collagen.
Biochimica et biophysica acta  •  1984  |  View Paper
When ADP or epinephrine was added to citrated platelet rich plasma (PRP) one minute after addition of heparin , marked enhancement of platelet aggregation was observed, compared with the degree of platelet aggregation in the absence of heparin.
Thrombosis research  •  1981  |  View Paper
Biphasic aggregation and release of platelet contents by ADP, epinephrine and collagen in dialysed plasma was inhibited by hirudin and heparin.
British journal of haematology  •  1978  |  View Paper
These data indicate that heparin increases the sensitivity of platelets to ADP and epinephrine as determined by platelet aggregation, and protamine added to heparinized blood not only reverses this effect, but decreases platelet sensitivity when it is added in concentration that neutralize heparin.
Anesthesiology  •  1978  |  View Paper
Heparin concentrations as high as 100 units/ml were found to suppress platelet alpha granule release induced by either a thromboxane A2 analog (U46619) or a combination of adenosine diphosphate and epinephrine.
Journal of vascular surgery  •  1992  |  View Paper
Heparin , when added to citrated platelet-rich plasma (PRP), caused potentiation of platelet aggregation and the release reaction induced by the aggregating agents adenosine diphosphate (ADP), arachidonic acid, collagen, and epinephrine.
The American journal of pathology  •  1981  |  View Paper
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