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Last Updated: 2 years ago

Possible Interaction: Epinephrine and Heparin

supplement:

Epinephrine

drug:

Heparin

Research Papers that Mention the Interaction

Heparin concentrations as high as 100 units/ml were found to suppress platelet alpha granule release induced by either a thromboxane A2 analog (U46619) or a combination of adenosine diphosphate and epinephrine.
Journal of vascular surgery  •  1992  |  View Paper
Heparin , when added to citrated platelet-rich plasma (PRP), caused potentiation of platelet aggregation and the release reaction induced by the aggregating agents adenosine diphosphate (ADP), arachidonic acid, collagen, and epinephrine.
The American journal of pathology  •  1981  |  View Paper
Thompson and colleagues [14] showed that heparin can increase platelet aggregation by ADP and adrenaline , both in vitro and in vivo.
British journal of clinical pharmacology  •  1998  |  View Paper
These results show that EPI contributes significantly to the anticoagulant effect of heparin in human blood.
Haemostasis  •  1991  |  View Paper
After antagonizing the heparin dose and supporting the right heart with epinephrine bleeding was reduced substantially, following which the right pulmonary artery was declamped.
Der Anaesthesist  •  1988  |  View Paper
In contrast, the affinity of the alpha-adrenoceptor for adrenaline was decreased in the presence of heparin.
The Biochemical journal  •  1988  |  View Paper
Heparin was found to increase slightly ADP and epinephrine induced aggregation and to decrease cAMP.
Arzneimittel-Forschung  •  1987  |  View Paper
Heparin potentiates the first aggregation step induced by ADP and epinephrine but inhibits aggregation induced by thrombin and ristocetin.
Folia haematologica  •  1984  |  View Paper
Heparin potentiates the aggregating effect of adenosine diphosphate (ADP) and epinephrine , but it is uneffective on the aggregation induced by ristocetin and collagen.
Biochimica et biophysica acta  •  1984  |  View Paper
When ADP or epinephrine was added to citrated platelet rich plasma (PRP) one minute after addition of heparin , marked enhancement of platelet aggregation was observed, compared with the degree of platelet aggregation in the absence of heparin.
Thrombosis research  •  1982  |  View Paper
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