Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Epinephrine and Halothane

supplement:

Epinephrine

Research Papers that Mention the Interaction

The arrhythmogenic dose of epinephrine CADE) during one MAC of halothane in dogs was increased from 1.13 ± 0.21 to 3.14 ± 0.89 μg·kg−l ± min−1 by the administration of 0.3 mg/kg of DL.
Anesthesia and analgesia  •  1985  |  View Paper
Katz and associates,3 on the other hand, considered injection of limited quantities of epinephrine during induction of anesthesia with halothane to be safe provided certain precautions were observed.
Anesthesia and analgesia  •  1968  |  View Paper
Halothane and pancuronium are contraindicated, while large doses of local anaesthetics and epinephrine should be avoided in neuraxial blocks.
British journal of anaesthesia  •  2012  |  View Paper
Sevoflurane (0.13-0.91 mM) and halothane (0.49-1.25 mM) inhibited secondary platelet aggregation induced by adenosine diphosphate (1-10 micro Meter) and epinephrine (1-10 micro Meter) without altering primary aggregation.
Anesthesiology  •  1996  |  View Paper
Cutaneous infiltration of dilute solutions of epinephrine for hemostasis during halothane anesthesia can result in ventricular dysrhythmias, Our clinical experience, published reports, and a study comparing piglets with adult swine suggest that children may be less susceptible than adults to dysrhythmias under these conditions.
The presence of PAC and tachycardia emphasize the need for continuous ECG monitoring and caution during halothane anesthesia with epinephrine injection.
Anesthesiology  •  1983  |  View Paper
Aggregation induced by halothane could be potentiated by small doses of adrenaline or ADP and in some individuals by caffeine.
British journal of anaesthesia  •  1983  |  View Paper
There should be no restriction to spontaneous respirations, however I cannot speak from experience as I prefer to avoid the combination of adrenaline and halothane even with controlled ventilation.
Anaesthesia  •  1981  |  View Paper
Increased cardiac sensitivity to epinephrine during halothane anesthesia has been well documented; however, there are few reports of increased cardiac irritability due to interaction between halothane anesthesia and aminophylline.
Anesthesia progress  •  1980  |  View Paper
Although, halothane has an excellent safety record and comes close to being the ideal inhalational anesthetic it does have some undesirable effects, including incompatibility with adrenaline and the possibility of causing disturbed hepatic function when given repeatedly.
Acta anaesthesiologica Belgica  •  1980  |  View Paper
Since the introduction of halothane as an anaesthetic there have been several reports about cardiac arrhythmias during application of epinephrine in combination with halothane.
Broncho-pneumologie  •  1978  |  View Paper
Show More