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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Haloperidol

supplement:

Epinephrine

Research Papers that Mention the Interaction

In contrast, ten subjects receiving haloperidol , a drug also effective in the treatment of mania, show a mean rise in plasma cyclic AMP levels after epinephrine administration and the magnitude of the response is the same as for non-drug treated individuals.
Psychopharmacology  •  2004  |  View Paper
Combined intramuscular injection of haloperidol and epinephrine in the threshold doses, ineffective in monotherapy, causes the maximum antipsychotic effect, but not catalepsy.
Hence, potentiation of the antipsychotic effect of haloperidol with epinephrine is related to stimulation of afferents in the gastric mucosa.
Preliminary anesthesia of the gastric mucosa with 1% lidocaine and blockade of intramural ganglia in the gastric mucosa with hexamethonium completely abolished the potentiated antipsychotic effects produced by combined treatment with haloperidol and epinephrine.
Bulletin of Experimental Biology and Medicine  •  2007  |  View Paper
Norepinephrine and epinephrine similarly inhibited POMC peptide secretion, but this effect was blocked by haloperidol , suggesting that it was mediated through a dopamine receptor.
Endocrinology  •  1989  |  View Paper