Possible Interaction: Epinephrine and Haloperidol

“In contrast, ten subjects receiving haloperidol , a drug also effective in the treatment of mania, show a mean rise in plasma cyclic AMP levels after epinephrine administration and the magnitude of the response is the same as for non-drug treated individuals.”

“Combined intramuscular injection of haloperidol and epinephrine in the threshold doses, ineffective in monotherapy, causes the maximum antipsychotic effect, but not catalepsy.”

“Hence, potentiation of the antipsychotic effect of haloperidol with epinephrine is related to stimulation of afferents in the gastric mucosa.”

“Preliminary anesthesia of the gastric mucosa with 1% lidocaine and blockade of intramural ganglia in the gastric mucosa with hexamethonium completely abolished the potentiated antipsychotic effects produced by combined treatment with haloperidol and epinephrine.”

“Infusion of adrenaline (10 nmol·kg−1, given in 15 s), in contrast to that of isoprenaline and phenylephrine (both the same concentration as adrenaline) also reduced the haloperidol induced catalepsy.”

“Norepinephrine and epinephrine similarly inhibited POMC peptide secretion, but this effect was blocked by haloperidol , suggesting that it was mediated through a dopamine receptor.”

“ Urinary epinephrine , but not norepinephrine was increased in the L-DOPA and haloperidol groups.”

“The effects of both dopamine and adrenaline are antagonized similarly by the alpha-adrenergic blocking agents, phentolamine and thymoxamine, as well as by haloperidol , but are not prevented by pretreatment with reserpine.”