Possible Interaction: Epinephrine and Guanethidine

“A significant increase in the hypotensive effect was found by adding guanethidine 1% to adrenaline 1%.”

“The patients on pilocarpine 4% and adrenaline 1% also had lower intraocular pressures on Ganda 5.05, but the significance was less, and the patients on separate guanethidine and adrenaline had a small but not statistically significant drop in pressure.”

“This study showed that an association of adrenaline and guanethidine in drop form, used in cases of open-angle glaucoma, achieved a rapid and lasting stabilisation of intraocular pressure.”

“The action of adrenaline in reducing aqueous production and improving outflow is enhanced by the supersensitizing action of guanethidine.”

“In rabbit isolated atria, cocaine, guanethidine and phenoxybenzamine increased the changes in rate and force of contractions caused by noradrenaline and adrenaline , but did not potentiate isoprenaline.”

“Cocaine and guanethidine enhanced the motor response to adrenaline , noradrenaline and phenylephrine while the action of dopamine was blocked by these two drugs.”

“Similarly, the synergism between adrenaline and guanethidine (in reality potentiation of the effect of adrenaline by guanethidine) can be assigned to a blockade of uptake of adrenaline into adrenergic neurones, thus increasing the effective local concentration of adrenaline at its site of action.”

“Professor Drance commented that the use of a combination of adrenaline and guanethidine might be of great importance in reducing the side-effects due to adrenaline alone.”

“Prolonged estrogen treatment or administration of progesterone, reserpine or guanethidine decreased the epinephrine content of the uterus.”

“La cocaïne, l'imipramine, la desméthylimipramine et la guanéthidine ont provoqué une accumulation accrue de la noradrénaline tritiée dans le vas deferens du rat, dans des conditions expérimentales où elles inhibaient fortement cette accumulation dans le cœur.”