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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Epinephrine
drug:
Guanethidine
Research Papers that Mention the Interaction
“The combination of ….5% with epinephrine 0.…% plus guanethidine 3 % had a stronger effect on intraocular pressure (reduction 10.9 +/- 1.1 mm Hg) than epinephrine 0.5% plus guanethidine …% (7.6 +/- 0.9 mm Hg) or timolol alone (5.8 +/- 1.1 mm Hg) or other glaucoma drugs.”
[Treatment of glaucoma chronicum simplex with a combination of 0.5 percent timolol with 0.5 percent adrenaline plus 0.3 percent guanethidine].“Prolonged estrogen treatment or administration of progesterone, reserpine or guanethidine decreased the epinephrine content of the uterus.”
“The administration of guanethidine (7.5 mg/kg) was found to produce a 3-fold sensitization to topically applied epinephrine within 10 minutes.”
MICROCIRCULATION: EFFECTS OF GUANETHIDINE AND RESERPINE.“4) Depletion of catecholamines or blockade of their release by reserpine or guanethidine also potentiates the epinephrine pressor response.”
EFFECTS OF ALTERATION OF SYMPATHETIC TONE UPON THE BLOOD PRESSURE RESPONSE TO EPINEPHRINE.“In such hearts, guanethidine causes an acute supersensitivity of the pacemaker to norepinephrine and epinephrine.”
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