Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Epinephrine and Guanethidine

supplement:

Epinephrine

Research Papers that Mention the Interaction

The combination of ….5% with epinephrine 0.…% plus guanethidine 3 % had a stronger effect on intraocular pressure (reduction 10.9 +/- 1.1 mm Hg) than epinephrine 0.5% plus guanethidine …% (7.6 +/- 0.9 mm Hg) or timolol alone (5.8 +/- 1.1 mm Hg) or other glaucoma drugs.
Klinische Monatsblatter fur Augenheilkunde  •  1989  |  View Paper
Prolonged estrogen treatment or administration of progesterone, reserpine or guanethidine decreased the epinephrine content of the uterus.
The Journal of pharmacology and experimental therapeutics  •  1962  |  View Paper
The administration of guanethidine (7.5 mg/kg) was found to produce a 3-fold sensitization to topically applied epinephrine within 10 minutes.
The Journal of pharmacology and experimental therapeutics  •  1963  |  View Paper
4) Depletion of catecholamines or blockade of their release by reserpine or guanethidine also potentiates the epinephrine pressor response.
The Journal of pharmacology and experimental therapeutics  •  1964  |  View Paper
In such hearts, guanethidine causes an acute supersensitivity of the pacemaker to norepinephrine and epinephrine.
The Journal of pharmacology and experimental therapeutics  •  1962  |  View Paper