Possible Interaction: Epinephrine and Glycerol

“Both isoproterenol and epinephrine induced a dose-dependent increase in extracellular glycerol concentration when infused for 60 min through the microdialysis probes before and during hours 3 and 6 of the clamp.”

“We conclude that 1) lactate is the predominant precursor for epinephrine-stimulated GNG in both liver and kidney, … and renal GNG from lactate and glycerol are similarly sensitive to stimulation by epinephrine, and 3) epinephrine increases renal … lactate and glycerol by increasing substrate availability and … efficiency of the kidney.”

“In women, epinephrine provoked a greater glycerol release than in men in both abdominal and femoral regions (P < .05).”

“The EPI infusion significantly increased serum concentrations of free fatty acids and glycerol.”

“In humans, infusion of epinephrine causes a transient two- to threefold increase in fatty acids, glycerol , and ketone bodies.”

“During microdialysis, epinephrine increased dialysate glycerol concentrations by 250% without and 254% with calcium.”

“ Epinephrine markedly increased glycerol production at each pH in both buffers, but significantly more was produced at pH 8.4 than at pH 7.4.”

“As regards glycerol the addition of adrenaline caused a ~ 20% increase of the concentration in adipose tissue but a ~ 20% decrease in the synovial membrane.”

“ Glycerol flux increased from 2.2±0.3 to 6.7±0.4 μmol/kg per minute (with the13C tracer) and from 2.2±0.3 to 6.7±0.3 μmol/kg per minute (with the2H tracer) when epinephrine was infused.”

“ Peak glycerol … epinephrine infusion after 84 hours of fasting (5.69 +/- 0.72 and 11.40 +/- 0.78 mumol/kg/min for hypertensive and normotensive subjects, … greater than at 12 hours (3.09 +/- 0.29 and 5.06 +/- 0.69 mumol/kg/min) in both hypertensive and normotensive subjects.”