Possible Interaction: Epinephrine and Glyburide

“Platelet aggregation in response to 10 mumol adrenaline and 750 micrograms/ml collagen was significantly reduced by glibenclamide (P less than 0,05).”

“8‐pCPT‐2′‐O‐Me‐cAMP, an Epac‐selective cAMP analogue, and glibenclamide, a sulfonylurea, synergistically activate Epac2A and Rap1, whereas adrenaline , which suppresses cAMP production in pancreatic β‐cells, blocks activation of Epac2A and Rap1 by glibenclamide.”

“Addition of 2 μM glibenclamide in the preincubation mixture reduced the inhibitory effect of glucagon by 99% (P < 0.05) and that of epinephrine by 70% (p < 0.01).”

“Addition of 2 μM glibenclamide significantly reduced the inhibitory effect of glucagon by 77% (P < 0.05) and that of epinephrine by 33% (P < 0.05).”

“Thus, glibenclamide opposes the inhibitory effect of glucagon and epinephrine on two key hepatic glycolytic enzymes.”

“In addition combined epinephrine and norepinephrine responses during hypoglycemia were reduced (p<0.05) following glyburide as compared to placebo.”

“Treatment with glyburide significantly reduced aggregation in response to 10 microM of epinephrine and collagen at 750 microgram/ml.”

“SummaryTolbutamide (1 mM) and glibenclamide (0.1 mM) reduced lipolysis due to adrenaline , noradrenaline, isoprenaline, glucagon, and ACTH, whereas theophylline-induced glycerol production was only marginally affected.”

“ Epinephrine produced second-degree or complete atrioventricular block in 4 out of 7 rats receiving glibenclamide.”