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Possible Interaction: Epinephrine and Glutathione

supplement:

Epinephrine

supplement:

Glutathione

Research Papers that Mention the Interaction

Cys, GSH and GSSG in the model system inhibit quinoid oxidation of adrenaline , as a result of which the formation of superoxide (O2 ·-) is also inhibited.
Biomeditsinskaia khimiia  •  2019  |  View Paper
Glutathione concentrations in the micromolar range, which correspond to levels in erythrocyte extracts, were capable of perturbing the epinephrine assay method and causing overestimation of enzyme content.
Analytical biochemistry  •  1984  |  View Paper
Abstract The reaction in neutral aqueous solution between an oxidation product of epinephrine and glutathione in moderate excess resulted in the accelerated disappearance of the sulfhydryl group, the absence of adrenochrome, and the formation of two separate glutathione-epinephrine derivatives with distinctive absorbancy and fluorescence.
Archives of biochemistry and biophysics  •  1965  |  View Paper
Abstract Cysteine and glutathione decreased the tyrosinase-induced development of adrenochrome from epinephrine and noradrenochrome from norepinephrine at pH 7.4.
Archives of biochemistry and biophysics  •  1959  |  View Paper
In hepatocytes 10 μM adrenaline (Adr), but not isoproterenol (Iso) a β-AR agonist, or phenylephrine (Phe) an α1-AR agonist, (in a Krebs-Henseleit buffer (KHB) enriched with Ca2+ and some aminoacids) increased in 13% GT efflux.
In livers perfused with KHB, Adr or Iso at 1 μmolar doses (but not Phe) stimulated 11-fold initial velocity of GT release, but only during the first 2 min of perfusion.
Archives of biochemistry and biophysics  •  2018  |  View Paper
However, especially epinephrine injection after adrenalectomy resulted in a significantly increase of measured antioxidant enzyme activities and GSH levels in both gastric tissue and erythrocyte.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2007  |  View Paper
Epinephrine modulated alpha-adrenoceptors to increase the levels of gastric mucosal nitric oxide and glutathione.
Shock  •  2005  |  View Paper
Addition of adrenaline (5 mM) and glutathione (0.1 mM) increased the activity of COX-2 in broken cell preparations.
British journal of pharmacology  •  1995  |  View Paper
Norepinephrine and epinephrine (both alpha and beta agonists) also stimulated GSH absorption but not to the same extent as phenylephrine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1991  |  View Paper
Since epinephrine and clonidine have been shown to decrease hepatic glutathione (GSH) by activating alpha 2-adrenoceptors, and alpha 2-antagonists partially antagonize GSH depletion and hepatotoxicity caused by bromobenzene and cocaine, we have investigated whether the formamidines would affect hepatic GSH levels in mice.
Journal of toxicology and environmental health  •  1991  |  View Paper
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