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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Epinephrine
supplement:
Glutamine
Research Papers that Mention the Interaction
“In …, EPI was demonstrated to increase estimated hepatic plasma flow (EHPF, mL/min: 1,019 +/- 133 [mean +/- SD] v 737 +/- 153; P less than .01), …), and splanchnic uptake of total AA (nmol/kg.min: 4,657 +/- 2,014 v 2,802 +/- 704; P less than .05), of Gln (+78%) …%).”
Effect of stress hormones on transsplanchnic balance of exogenous amino acid in healthy man.“ Adrenaline caused sustained increases in Vs and Q , while Rsys only rose transiently.”
Circulatory function at sub-zero temperature: venous responses to catecholamines and angiotensin II in the Antarctic fish Pagothenia borchgrevinki“ Adrenaline caused a partial inhibition of glutamine utilization by neutrophils, an effect that was also blocked by propranolol.”
“However, when rat neutrophils were incubated in the presence of glutamine plus adrenaline (5 nM or 50 microM), the rate of superoxide production was only marginally reduced.”
“We postulate that glutamine metabolism may thus provide a protective mechanism against the inhibitory effect of adrenaline on superoxide production by neutrophils.”
“ Glutamine oxidation was also stimulated by adrenaline thus providing increased substrate (malate) for NADP(+)-dependent 'malic' enzyme and therefore shifting some of the burden of NADPH production from glucose to glutamine metabolism.”
“However, in muscles of rats subjected to 2 h prior exercise or water immersion, 10(-7) M adrenaline significantly increased the release of glutamine (+ 48% and +34%, P less than 0.05) and glutamate (+38% and +27%, P less than 0.05).”
“Serotonin (10(-5) M) and epinephrine (10(-5) M) inhibited alanine and glutamine release equally in preparations from 6-hydroxydopamine-pretreated as compared to control rats.”
“… epinephrine … glutamine release from control preparations, but no inhibition was observed from diabetic preparations with <0.1 mM. 10 nM epinephrine stimulated lactate production from control … preparations was observed only at 0.1 mM. Serotonin inhibited amino acid release and stimulated lactate production equally in control and diabetic muscle.”
“ Epinephrine increases the output and tissue content of ammonia and glutamine.”
“With control muscles, 1 nm or greater, epinephrine inhibited alanine and glutamine release, whereas with uremic muscles, epinephrine concentrations <1 muM did not alter amino acid release.”
“ Epinephrine reduced the release of alanine and glutamine in a concentration-dependent manner.”
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