Adrenomedullary Response to Glucagon in Patients with Primary Sjögren’s Syndrome

 levels increased (P < 0.01) in response to 

 administration while norepinephrine concentration did not change.

Ventilatory effects of the stress hormones in normal man.

Increases in plasma levels of cortisol and

 during stress may exert a synergistic effect with 

; ventilatory effects are augmented in relation to the changes in VO2.

Epinephrine's effect on metabolic rate is independent of changes in plasma insulin or glucagon.

 and insulin have been reported to affect thermogenesis, these hormones might contribute to or modify the thermogenic response to 

Effect of epinephrine and somatostatin-induced insulin deficiency on ketone body kinetics and lipolysis in man.

 administration resulted in hyperglycemia, hyperlactatemia, and a modest increase in plasma insulin and 

Epinephrine supports the postabsorptive plasma glucose concentration and prevents hypoglycemia when glucagon secretion is deficient in man.

Thus, postabsorptive hypoglycemia occurs when both

 are deficient, but not when either glucagon or epinephrine alone is deficient, and insulin is present.

Oral glucose tolerance test (OGTT) during epinephrine infusion in three patients with insulomas.

 infusion (6 mug/min) in three patients with insulomas inhibited insulin secretion induced by OGTT and increased 

 secretion in two patients, with an exceptional rise in a case of poly-adenomatosis.

Studies on the mechanism of epinephrine-induced hyperglycemia in man. Evidence for participation of pancreatic glucagon secretion.

Glucagon and plasma catecholamine responses to graded and prolonged exercise in man.

 concentrations correlated significantly with norepinephrine and 

 concentrations during prolonged and with epinephrine during graded exercise.

Uncontrolled diabetes mellitus and hyperglucagonemia associated with an islet cell carcinoma.

 levels were markedly increased with arginine and 

Stimulation of glucagon secretion by epinephrine in man.

 secretion in man while inhibiting insulin release.

Elevation of plasma epinephrine levels produced by glucagon in vivo.

 (0.1 mg/min) produced a marked elevation of both 

 and norepinephrine in adrenal vein blood.

 (50 μg/kg) given to anesthetized dogs rapidly elevates glucose, lactate and 

Relationship of the adrenal medulla to the hyperglycemic effect of glucagon.

It is concluded that depression of the rate of peripheral glucose uptake by

 is a prerequisite for the hyperglycemic effect of 

, though not for its glycogenolytic action.

Glucose, adrenaline and palmitate antagonistically regulate insulin and glucagon secretion in human pseudoislets

 secretion 2-fold at low glucose, an effect suppressed by high glucose.

Adenosine 3',5'-monophosphate-dependent and -independent inhibitory effects of epinephrine on insulin release in rat pancreatic islets.

In contrast to the inhibitory effects of a high concentration of

 and glucose-stimulated increases in islet [3H]cAMP, this concentration of epinephrine did not decrease the increased [3H]cAMP le...

Epinephrine and the regulation of glucose metabolism: effect of diabetes and hormonal interactions.

In normal subjects, the hyperglycemic action of

 is enhanced by simultaneous elevations of 

Role of glucagon in mediating metabolic effects of epinephrine.

 mediates the early glycogenolytic response to 

, but not the delayed hyperglycemia and probably not the lipolysis.

Glucagon's actions are modified by the combination of epinephrine and gluconeogenic precursor infusion.

 have additive effects on both gluconeogenic and glycogenolytic flux.

Bicuculline methiodide influences the central nervous system to produce hyperglycemia in rats.

Three possible mechanisms are suggested to account for the rise in plasma glucose in the hepatic … after injection of BMI: 1) that epinephrine is secreted by the adrenal medulla, 2) that

 secretion or 3) that there may be some direct innervation of the liver in rats.

Interaction of salmon glucagon, glucagon-like peptide, and epinephrine in the stimulation of phosphorylase a activity in fish isolated hepatocytes.

Measuring the balance between insulin synthesis and insulin release.

 or of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate the cells also released 3-fold more hormone that they synthesized; release was however reduced to 25% of the rate of production in the presence of 

Desensitization of β-Receptor Mediated Responses to Epinephrine in Fetal Lambs by Prolonged Ritodrine Administration

 significantly increased plasma FFA, lactate, glucose, and 

Stimulation of gastric glucagon secretion by epinephrine administration in dogs.

 elicits a prompt and significant increase in 

 concentrations in the gastric vein which persist during the time of hormone infusion.

The effects of epinephrine on islet hormone secretion in the dog

 increased plasma epinephrine levels to 918±103 pg/ml (P<0.001), and increased the baseline pancreatic output of insulin (P<0.05), 

Plasma glucose levels increased slightly and transiently during infusion of epinephrine from 99±2 mg/dl …±3 mg/dl (P<0.05).An IV infusion of 80 ng/kg/min of

 produced plasma epinephrine levels of 2948±281 pg/… pancreatic output of insulin (P<0.05) and 

Effects of epinephrine, glucagon and insulin on the activity and degree of phosphorylation of fructose-1,6-bisphosphatase in cultured hepatocytes.

 was completely reciprocated by insulin and the action of insulin was totally erased by the other two.

Epinephrine potentiates adenosine-stimulating effect on glucagon secretion.

 administered at a low concentration (0.01 microM) was ineffective on 

 secretion, and adenosine at 1.65 microM was previously shown to be moderately stimulating.

Lack of effect of somatostatin on epinephrine-stimulated glucose production in the dog.

 levels at five minutes of plus 9 +/- 1 microU/mL and minus 1 +/- 3 pg/mL, respectively, and averaged plus 6 +/- 2 microU/mL and minus 9 +/- 5 pg/mL over the first hour.

Effects of beta non-selective and beta1 selective adrenergic blocking agents on glucagon secretion from isolated perfused rat pancreas

 infusion (at 10−7 M) caused a prompt and sustained increase in basal IRG secretion and significantly potentiated 

 release in response to metabolic stimulus.

Glucagon and epinephrine suppression of food intake in liver-denervated rats.

 (30 micrograms/kg) decreased food intake more than 

 but caused less hyperglycemia than any glucagon dose.

Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats.

 enhances glucose recovery by decreasing glucose clearance rather than by increasing glucose production, at least when 

Studies of the interaction between glucagon and alpha-adrenergic agonists in the control of hepatic glucose output.

 (10 nM) were able to inhibit phosphorylase activation and glucose output elicited by low doses of 

 (acting via alpha 1-adrenergic receptors), vasopressin, and angiotensin II to elicit calcium efflux was inhibited by 

, suggesting that intracellular redistributions of Ca2+ are importantly involved in the gluconeogenic process.

Modulation by the hypothalamus of glucagon and insulin secretion in rabbits: studies with electrical and chemical stimulations.

It is concluded that the actions of acetylcholine in the VMH, probably though activation of nicotinic receptor, and of

 in the LHN are important for hypothalamic modulation of the selective releases of 

Interaction of glucagon and epinephrine in the regulation of adenosine 3',5'-monophosphate-dependent glycogenolysis in the cultured fetal hepatocyte.

, it elicited a second glycogenolytic response, so that the amount of glycogen degraded represented 80% of the stored glycogen.

Physiologic effects of epinephrine on glucose turnover and plasma free fatty acid concentrations mediated independently of glucagon.

It has been suggested that the effects of

 on glucose production by the liver may be mediated through 

 (0.1 μ g/kg-min) had a similar but less definite effect on glucose regulation and caused both insulin and 

A comparison of adrenalin and glucagon effects on carbohydrate levels of larval and adult Rana pipiens.

Abstract Hyperglycemia was observed in frogs after single ip injections of doses above 50 μg/kg of

Influence of somatostatin on glucagon- and epinephrine-stimulated hepatic glucose output in the dog.

, the rise in glucose production was reduced in 65% despite replacement of glucagon levels and presumably mild portal insulin deficiency.

Insulin antagonistic effects of epinephrine and glucagon in the dog.

 increased glucose output twofold, suppressed glucose clearance, and caused a 15--30 mg/dl increase in plasma glucose despite ongoing hyperinsulinemia.

Synergistic interactions of physiologic increments of glucagon, epinephrine, and cortisol in the dog: a model for stress-induced hyperglycemia.

 on glucose clearance predominated, thereby accounting for the exaggerated glycemic response to combined infusion of 

, the rise in glucose production was additive, albeit transient.

 infusion was accompanied by a rise in glucose clearance, with 

 there was a sustained, 20% fall in glucose clearance.

The influence of endogenous glucagon release on hyperglycemic responses to catecholamines in normal fed and diabetic rats.

 release and inhibited insulin secretion.

Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: effects of somatostatin.

 produced dose-related increases in plasma glucose and 

 levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia.

Effects of exogenous glucagon and epinephrine in physiological amounts on the blood levels of free fatty acids and glycerol in dogs

Plasma levels of glycerol and free fatty acids remained unchanged during the

 infusion, but rose significantly during the administration of 

Effects of epinephrine and insulin on phosphopeptide metabolism in adipocytes.

Norepinephrine, dibutyryl N6,O2'-dibutyryl adenosine 3':5'-monophosphate, adrenocorticotropic hormone (ACTH) (synthetic 1 to 24 fragment), and

Studies on glucagon secretion using isolated islets of langerhans of the rat

The effects of hormones and prostaglandins on the calcium pools in cultured myocardial cells

 were found to produce significant increases in the size of the two slower exchanging pools.

[Participation of catecholamines in the inhibition of insulin secretion and stimulation of glucagon release during exercise and stress (author's transl)].

In addition to inhibiting insulin secretion,

 release in vitro, using pieces of pancreas from duct-ligaturated rats incubated at both low and high glucose concentrations.

Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats.

 can stimulate gluconeogenesis from 2 mM lactate nearly 4-fold in isolated liver cells from fed rats; exogenous cyclic adenosine 3':5'-monophosphate (cyclic AMP) is equally effective, but 

Regulation of glycogen metabolism in liver by the autonomic nervous system. VI. Possible mechanism of phosphorylase activation by the splanchnic nerve.

The activity of dephospho-phosphorylase kinase increased about 2--3-fold 1 min after injections of

, glucagon causing more activation than epinephrine.

, the nucleotide concentration rose to a maximum after 1 min and amounted to about 3-fold increase, while with 

 the maximum increase of approximately 8-fold increase was observed after 2 min.

Interaction of glucagon and catecholamines in the regulation of serine dehydratase.

 was effective in inhibiting the normal glucagon induction when administered 1 hr before, 2 hr after or simultaneously with 

The level of cAMP in the livers of rats receiving

 was elevated over control values at time points between 5 and 20 min but was lower than the level in animals receiving only glucagon which remained elevated until at least 60 min after injection.

Metabolic regulation of heme catabolism and bilirubin production. I. Hormonal control of hepatic heme oxygenase activity.

 to a fivefold, increase of hepatic HO activity; arginine, which releases endogenous glucagon, stimulated the enzyme fivefold.

Studies on the role of adenosine 3',5'-monophosphate in the hepatic actions of glucagon and catecholamines.

 produced detectable increases in liver cyclic AMP within 30 sec. With 

, the level of cyclic AMP rose to a maximum at 3 min and declined slowly over 1 hour.

Effect of glucagon on cyclic 3',5'-AMP, phosphorylase activity and contractility of heart muscle of the rat.

The two drugs were about equally effective except that the maximal augmentation of contractility by

 (5 x 10-9 moles) was twice that produced by an equivalent dose of 

 with a fourfold greater increase in cyclic AMP concentration.

Alterations in glucose turnover following single intravenous injections of epinephrine and glucagon in dogs.

, Rd increased 1.5- to 2-fold during the first 10 minutes; it returned to control levels 10 minutes after epinephrine and 30 minutes after glucagon.

The role of cyclic AMP in the control of liver metabolism.

3.|The accumulation of cyclic AMP in the liver is promoted by much lower levels of glucagon than catecholamines and the maximum cyclic AMP concentration with

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Possible Interaction: Epinephrine and Glucagon

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Research Papers that Mention the Interaction