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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
supplement:
Gamma-Linolenic Acid
Research Papers that Mention the Interaction
“Platelet aggregation induced by low concentrations of adenosine diphosphate (ADP) and epinephrine , and serum thromboxane B2 decreased by 45% both in humans and animals after GLA supplementation.”
Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production.“Namely, the Ω-6 arachidonic and linoleic acids, based on their effect on CA release and cellular content, seemed to impair NA and AD vesicular transport, whereas γ-linolenic acid selectively impaired AD synthesis and release.”
Dietary unsaturated fatty acids differently affect catecholamine handling by adrenal chromaffin cells.“Glucagon, dibutyryl cyclic AMP, and epinephrine decreased the oxidative desaturation of linoleic acid to γ-linolenic acid while the elongating reaction was not modified in the experimental conditions tested.”
“The … epinephrine (1 mg/kg body weight) 12 hr before killing, produced … 50% decrease in desaturation of [1-14C]linoleic acid to γ-linolenic acid , [1-14C]α-linolenic acid to octadeca-6,9,12,15-tetraenoic … and [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid.”
“ Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to gamma-linolenic acid.”
“Administration of epinephrine (1 mg/kg body weight) produced a significant decrease in desaturation of [l-14C]=linoleic acid to gamma-linolenic acid and of [L-14C]alpha-linolenic acid to actadeca-6,9,12,15-tetraenoic acid 12 hr after the infection.”
“ Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to γ-linolenic acid.”
Effect of catecholamines and β-blockers on linoleic acid desaturation activity
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