Possible Interaction: Epinephrine and Flurbiprofen

“ Ocufen had an additive effect with epinephrine ; the group with Ocufen + epinephrine treatment had a smaller proportion of cases with pupil size decreases than the group with epinephrine alone.”

“ Flurbiprofen causes marked inhibition of the secondary phase of platelet aggregation induced by adenosine diphosphate and adrenaline as well as collagen-induced aggregation in vitro and in vivo.”

“Regular administration of flurbiprofen caused a persistent inhibition of the biphasic response and a reduction in the degree of platelet aggregation with adrenaline ; it also prolonged the lag phase and reduced both the slope and degree of aggregation with collagen.”

“ Abstract Flurbiprofen , a potent anti-inflammatory agent, has been shown to inhibit human platelet aggregation induced in vitro by adenosine diphosphate (ADP), adrenaline , collagen and thrombin.”

“ Epinephrine enhanced the direct delivery of FP into the agar gel to more than ten times its former level, in spite of the fact that it had no effect on systemic delivery.”

“and topically applied 0.03% flurbiprofen antagonized the ocular hypotensive effect of one drop (50 microliters) of 1% epinephrine.”

“10,11 Topical application of indomethacin or flurbiprofen (FL), inhibitors of PG synthesis, block the ocular hypotensive effect of topically applied epinephrine in rabbit, 12-14 normotensive monkey, and glaucomatous monkey'5 eyes.”