Possible Interaction: Epinephrine and Fluorides

“ Fluoride also reduced the stimulative effect of adrenaline on glycerol production, but not that of glucagon.”

“Although epinephrine stimulated adenylate cyclase 8-fold and fluoride 12-fold throughout the life-span of the rat, stimulated activity paralleled basal levels, decreasing 60% between 2 and 24 mo per mg protein and 40% between 6 and 24 mo per cell.”

“In lysates from both toxin-treated and control cells, maximally stimulating amounts of epinephrine and fluoride , when added in combination, have a nearly additive effect on cyclase activity.”