Possible Interaction: Epinephrine and Fluorides

“ Fluoride also reduced the stimulative effect of adrenaline on glycerol production, but not that of glucagon.”

“Increased adrenaline concentration could not overcome the inhibitory effect of fluoride.”

“Although epinephrine stimulated adenylate cyclase 8-fold and fluoride 12-fold throughout the life-span of the rat, stimulated activity paralleled basal levels, decreasing 60% between 2 and 24 mo per mg protein and 40% between 6 and 24 mo per cell.”

“In lysates from both toxin-treated and control cells, maximally stimulating amounts of epinephrine and fluoride , when added in combination, have a nearly additive effect on cyclase activity.”