supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Flecainide
Research Papers that Mention the Interaction
“Pretreatment with mexiletine was associated with a signifi cantly greater fall in serum potassium during … with flecainide with a greater fall in serum magnesium, as compared with placebo pretreatment Flecainide also caused a … duration before adrenalin infusion, and after all the active pretreatments … duration was seen during adrenaline infusion.”
Metabolic, Hemodynamic, and Electrocardiographic Responses to Increased Circulating Adrenaline: Effects of Pretreatment with Class 1 Antiarrhythmics“The arrhythmogenic doses of epinephrine in the presence of flecainide were 8.2 ± 2.2 (mean ± sd), 7.4 ± 6.1, 5.5 ± 2.8, and 2.0 ± 0.5 &mgr;g/kg in intact and diabetic rats 2, 4, and 6 wk after streptozotocin administration, respectively.”
Diabetes Mellitus Reduces the Antiarrhythmic Effect of Ion Channel Blockers“ Flecainide , E-4031, and verapamil markedly reduced the duration of arrhythmias induced by epinephrine , 8 µg/kg intravenously (P < 0.01), whereas only amiodarone markedly reduced the duration of arrhythmias Induced by epinephrine, 16 µg/kg intravenously (P < 0.01).”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback