Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Epinephrine and Fentanyl

supplement:

Epinephrine

Research Papers that Mention the Interaction

CONCLUSION The results suggest that adding epinephrine to a combination of standard intrathecal doses of bupivacaine and fentanyl in combined spinal-epidural analgesia for labor significantly prolongs spinal analgesia.
International journal of obstetric anesthesia  •  2005  |  View Paper
UNLABELLED We have shown that epinephrine markedly improves the analgesic effect of a thoracic epidural infusion of bupivacaine and fentanyl.
We conclude that epinephrine improves the pain relief and reduces the side effects of a thoracic epidural infusion of ropivacaine and fentanyl after major thoracic or upper abdominal surgery.
Anesthesia and analgesia  •  2002  |  View Paper
Our data also show that the total required dose of epidural, but not IV, fentanyl is reduced by very small dose epidural bupivacaine and epinephrine (Group I versus Group IV, P < 0.02 and Group II vs Group III, not significant).
Anesthesia and analgesia  •  2002  |  View Paper
BACKGROUND The highly lipid-soluble opioids, fentanyl and sufentanil, frequently are used in combination with local anesthetic agents and/or epinephrine to provide postoperative epidural analgesia.
Anesthesiology  •  1993  |  View Paper
The authors conclude that the addition of epinephrine 3.33 micrograms/ml significantly increases the duration of analgesia obtained from 0.25% bupivacaine with 5 micrograms/ml fentanyl.
Anesthesiology  •  1990  |  View Paper
The results suggest that both fentanyl and epinephrine improve intraoperative analgesia.
Ma zui xue za zhi = Anaesthesiologica Sinica  •  1989  |  View Paper
The addition of epinephrine to solutions containing fentanyl and bupivacaine for epidural infusion has been shown to improve the quality of analgesia.
Anaesthesia  •  2004  |  View Paper
The addition of 25 micrograms epinephrine to the fentanyl (100 micrograms) did not potentiate the speed of onset but did significantly prolong the duration of action of the second dose.
The results indicate a clinical advantage of prolonging the duration of action of fentanyl for post-Caesarean Section analgesia with the addition of epinephrine , but the cumbersome and time-consuming nature of a double-bolus technique limits its clinical value.
Canadian Anaesthetists' Society journal  •  1985  |  View Paper
Epinephrine had no effect on the terminal elimination half-life of morphine in the epidural space, but it decreased that of fentanyl and sufentanil.
Anesthesiology  •  2003  |  View Paper
This indicates that fentanyl has less suppressing action on the secretion of stress hormones, including epinephrine , under similarly stressful conditions as halothane anesthesia.
Masui. The Japanese journal of anesthesiology  •  1994  |  View Paper
Show More