“The addition of adrenaline to solutions of etidocaine or lignocaine for extradural administration resulted in significantly lower plasma koncentrations in both the arterial blood (14% decrease for etidocaine and 43% decrease for lignocaine) and venous blood (35% and 60% decreases for etidocaine and lignocaine respectively).”
“The nett absorption over the first 4 h after administration, measured from the area under the plasma concentration-time curve, was decreased by the addition of adrenaline (18% and 30% decreases for etidocaine and lignocaine respectively).”