Possible Interaction: Epinephrine and Estradiol

“ Epinephrine inhibited the effects of estradiol to increase uterine weight, phosphorylase a activity and glycogen deposition.”

“Tamoxifen did not influence the human platelet aggregation in vitro, while estradiol at a concentration of 10(-6) M inhibited the aggregation of human thrombocytes induced by ADP, serotonin + adrenaline , and adrenaline (epinephrine) by 14.7, 12.5, and 16.6%, respectively.”

“Norepinephrine, epinephrine , isoproterenol, and OR486 (COMT inhibitor) abrogated the inhibitory effects of estradiol on SMC growth and ERK1/2 phosphorylation.”

“Norepinephrine, epinephrine , and isoproterenol abrogated the inhibitory effects of estradiol on cell number, DNA synthesis, and collagen synthesis.”

“Norepinephrine, epinephrine , and isoproterenol inhibited the conversion of both estradiol and 2-hydroxyestradiol to 2-methoxyestradiol.”

“Finally, estradiol in a concentration-dependent manner suppressed 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) activity in H295R adrenal cells.”

“The results also supported the possibility that increased tissue concentrations of adrenal androgens inhibit oestradiol and thus increase tissue exposure to oestradiol.”

“In most cases the Ki value was approximately 10(-7) M. At micromolar concentrations several steroids, notably estrone and estradiol , caused almost total inhibition of adrenal 3 beta-HSD activity.”

“The aim of the present study was to investigate the hypothesis that adrenal androgens are contributory to the development of endometrial cancer either by the oestrogenic action of 5-androstene-3 beta, 17 beta-diol (androstenediol) or through the inhibition of oestradiol metabolism.”

“The adult adrenal cells in the presence of ACTH showed a much higher cortisol-DHA secretion ratio (on average 60-hold higher) but the addition of oestradiol markedly reduced this ratio as in foetal cells.”

“ EP or NE significantly increased the ovulation rate and plasma concentrations of estradiol-17beta , progesterone, zinc and triglyceride compared with control treatment.”