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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Esmolol

supplement:

Epinephrine

drug:

Esmolol

Research Papers that Mention the Interaction

BACKGROUND Animal studies on cardiac arrest found that a combination of epinephrine with esmolol attenuates post-resuscitation myocardial dysfunction.
Current pharmaceutical design  •  2019  |  View Paper
The administration of epinephrine significantly increased the contractile amplitude, force, and frequency whereas esmolol markedly decreased these contractile properties.
Analytical chemistry  •  2013  |  View Paper
RESULTS Injection of esmolol combined with epinephrine during CPR significantly decreased recurrent rate of ventricular fibrillation during 2-h post-resuscitation, meanwhile it has no adverse affect on the restore of spontaneous circulation.
Resuscitation  •  2009  |  View Paper
The beta(1) adrenergic effects of epinephrine were blocked with esmolol.
The Journal of pharmacology and experimental therapeutics  •  1999  |  View Paper
The number of countershocks required for restoration of spontaneous circulation was significantly greater for epinephrine-treated animals (10 +/- 8) when compared with phenylephrine-treated animals (1.8 +/- 0.4, P < .01) and with animals treated with epinephrine combined with esmolol (1.6 +/- 0.9, P < .01).
Circulation  •  1995  |  View Paper