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Possible Interaction: Epinephrine and Ergotamine

supplement:

Epinephrine

supplement:

Ergotamine

Research Papers that Mention the Interaction

Ergotamine potentiates the pressor effects of epinephrine and nor-epinephrine and reverses the depressor effects of Isuprel and isopropyl nor-sympatol.
Ergotamine prevents the vasomotor reversal of epinephrine by usually effective doses of the above adrenergic blocking agents, and supra-adrenolytic doses of the blocking agents are necessary to produce their typical action in ergotaminized animals.
Journal of the American Pharmaceutical Association. American Pharmaceutical Association  •  1951  |  View Paper
In dogs under nembutal anesthesia it was shown that ergotamine at certain dose levels not only does not reverse, but actually potentiates, the pressor effect of epinephrine.
Journal of the American Pharmaceutical Association. American Pharmaceutical Association  •  1949  |  View Paper
Ergotamine reverses the pressor effect of epinephrine but not of nor-epinephrine.
The American journal of medicine  •  1948  |  View Paper
Complete blockade of the liver phosphorylase response to epinephrine was observed with the α-adrenergic blocking agent ergotamine.
Biochemical pharmacology  •  1963  |  View Paper
The pressor responses to intravenously administeted epinephrine and l -arterenol are potentiated by small doses of ergotamine and ergotoxine.
The Journal of pharmacology and experimental therapeutics  •  1950  |  View Paper
Ergotamine tartrate (14 μg/kg.min) while not preventing a rise in plasma sugar concentration, inhibited the expected insulin decrease during epinephrine infusion.
Diabetologia  •  2005  |  View Paper
one commenced 1 h before the injection of epinephrine plus ergotamine and one just after injection, resulted in the prevention of rat tail gangrene in a dose-dependent manner, whereas sarpogrelate (100 mg/kg) produced a minimal protection in this model.
Vascular pharmacology  •  2004  |  View Paper
The stimulation of contractility by epinephrine , but not prostaglandin was inhibited by the α-blocking agent, ergotamine tartrate.
Prostaglandins  •  1973  |  View Paper
It is concluded that at least two factors are involved in the elicitation of preasor responses to epinephrine and isoproterenol after ergotamine , namely, the unaffected cardiostimulant action of the amines and the reduction in the capacity of the vascular bed caused by ergotamine.
The Journal of pharmacology and experimental therapeutics  •  1970  |  View Paper