Possible Interaction: Epinephrine and Ergotamine

“ Ergotamine potentiates the pressor effects of epinephrine and nor-epinephrine and reverses the depressor effects of Isuprel and isopropyl nor-sympatol.”

“ Ergotamine prevents the vasomotor reversal of epinephrine by usually effective doses of the above adrenergic blocking agents, and supra-adrenolytic doses of the blocking agents are necessary to produce their typical action in ergotaminized animals.”

“In dogs under nembutal anesthesia it was shown that ergotamine at certain dose levels not only does not reverse, but actually potentiates, the pressor effect of epinephrine.”

“ Ergotamine reverses the pressor effect of epinephrine but not of nor-epinephrine.”

“one commenced 1 h before the injection of epinephrine plus ergotamine and one just after injection, resulted in the prevention of rat tail gangrene in a dose-dependent manner, whereas sarpogrelate (100 mg/kg) produced a minimal protection in this model.”

“The stimulation of contractility by epinephrine , but not prostaglandin was inhibited by the α-blocking agent, ergotamine tartrate.”

“ Ergotamine has been shown to block the stimulant effect of adrenaline on the vesical sphincter (1) but it does not block the inhibitory effect on the detrusor muscle (1).”

“It is concluded that at least two factors are involved in the elicitation of preasor responses to epinephrine and isoproterenol after ergotamine , namely, the unaffected cardiostimulant action of the amines and the reduction in the capacity of the vascular bed caused by ergotamine.”

“The small doses of ergotamine used may weaken or abolish the vasoconstrictor action of adrenaline on cerebral vessels.”

“Complete blockade of the liver phosphorylase response to epinephrine was observed with the α-adrenergic blocking agent ergotamine.”

“The pressor responses to intravenously administeted epinephrine and l -arterenol are potentiated by small doses of ergotamine and ergotoxine.”