Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Epinephrine and Epoprostenol



Research Papers that Mention the Interaction

Furthermore, pretreatment with a tyrosine kinase inhibitor, genistein, or a cAMP-elevating agent, prostacyclin (PGI2), significantly reduced these synergistic effects of epinephrine.
Journal of biochemistry  •  1997  |  View Paper
Prostaglandin I2 (PGI2), which increases intracellular cyclic AMP, suppressed the formation of small as well as large aggregates induced by epinephrine , with ID50 values of 10.7 +/- 2.8 and 3.8 +/- 0.5 nM, respectively.
Journal of cardiovascular pharmacology  •  1996  |  View Paper
It took 24 hrs however for epinephrine at a level of 200 microM to inhibit [3H]thymidine incorporation and prostacyclin production.
Research communications in molecular pathology and pharmacology  •  1995  |  View Paper
Epinephrine added to ADP aggregates before or after PGI2 blocked disaggregation, or stopped dissociation if already in progress, and caused a rapid fall in the high levels of cAMP stimulated by PGI2.
Prostaglandins and medicine  •  1980  |  View Paper
Epinephrine … PGI2 production in a dose-dependent parallel manner, but the responses were distinct above 10(-6) M. Characterization of the nonfat cells by fractionation on … by measurement of angiotensin-converting enzyme activity and 6-keto-PGF1 alpha production indicated that the nonfat cells were predominantly vascular endothelial cells.
Diabetes  •  1989  |  View Paper
The cytoprotective effect of PGI2 was decreased significantly when it was given together with Degranol, tetracycline, actinomycin D, cimetidine, atropine, epinephrine and surgical vagotomy.
The PGI2 ( in a dose of 5 μg/kg) decreased significantly the ulcer preventive effect of Degranol, tetracycline, cimetidine, atropine, epinephrine and of surgical vagotomy; while the effects of actinomycin D, pentagastrin and 2,4-dinitrophenol were significantly increased by PGI2 administration.
Prostaglandins, leukotrienes, and medicine  •  1982  |  View Paper
Epinephrine can mobilize the reserve capacity of the slow mechanism, and prostacyclin that of the fast one.
Advances in myocardiology  •  1982  |  View Paper