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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Epoprostenol
Research Papers that Mention the Interaction
“Furthermore, pretreatment with a tyrosine kinase inhibitor, genistein, or a cAMP-elevating agent, prostacyclin (PGI2), significantly reduced these synergistic effects of epinephrine.”
Tyrosine phosphorylation and Syk activation are involved in thrombin-induced aggregation of epinephrine-potentiated platelets.“ Prostaglandin I2 (PGI2), which increases intracellular cyclic AMP, suppressed the formation of small as well as large aggregates induced by epinephrine , with ID50 values of 10.7 +/- 2.8 and 3.8 +/- 0.5 nM, respectively.”
“It took 24 hrs however for epinephrine at a level of 200 microM to inhibit [3H]thymidine incorporation and prostacyclin production.”
“Our study demonstrates that high circulating levels of adrenaline are associated with increased formation of prostacyclin.”
“The staurosporine-insensitive aggregation was strongly potentiated by adrenaline, an alpha 2-adrenergic agonist; adrenaline also counteracted the inhibition induced by prostacyclin and nitroprusside, with no appreciable effect on the cAMP levels and on the cyclic nucleotide-dependent protein phosphorylation.”
“ Epinephrine , an antagonist of adenylate cyclase inhibited the cytochemical reaction stimulated by prostacyclin.”
“ PGI2 prevented the thrombin-induced increase in [Ca2+]i and adrenaline antagonized the effect of PGI2.”
“ Epinephrine added to ADP aggregates before or after PGI2 blocked disaggregation, or stopped dissociation if already in progress, and caused a rapid fall in the high levels of cAMP stimulated by PGI2.”
“The cytoprotective effect of PGI2 was decreased significantly when it was given together with Degranol, tetracycline, actinomycin D, cimetidine, atropine, epinephrine and surgical vagotomy.”
“The PGI2 ( in a dose of 5 μg/kg) decreased significantly the ulcer preventive effect of Degranol, tetracycline, cimetidine, atropine, epinephrine and of surgical vagotomy; while the effects of actinomycin D, pentagastrin and 2,4-dinitrophenol were significantly increased by PGI2 administration.”
Cellular mechanisms of the development of gastric mucosal damage and of gastrocytoprotection induced by prostacyclin in rats. A pharmacological study.“ Epinephrine can mobilize the reserve capacity of the slow mechanism, and prostacyclin that of the fast one.”
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