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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Dexmedetomidine
Research Papers that Mention the Interaction
“ Dexmedetomidine also prevented an increase in plasma epinephrine concentration following tourniquet inflation (p = 0.003).”
Dexmedetomidine premedication before intravenous regional anesthesia in minor outpatient hand surgery.“Compared with controls, dexmedetomidine treatment also decreased adrenaline and noradrenaline levels significantly (mean difference in the percent changes from baseline: −90.41 (−145.79, −35.03)%; P < 0.05 and −62.82 (−85.47, −0.40.17)%; P < 0.05, respectively).”
“Objective Among the drugs for reducing hyperdynamic effects, dexmedetomidine and remifentanil are expected to blunt the acute hemodynamic responses after intranasal injection of epinephrine.”
“ DEX infusion during the perioperative period inhibited release of epinephrine , norepinephrine, and cortisol; decreased blood glucose, interleukin (IL)-6, tumour necrosis factor-α, and C-reactive protein; and increased interleukin-10 in surgical patients.”
“DEX administration and higher DEX concentrations attenuated lorazepam administration in the short-term and suppressed EPI.”
“ DEX utilization suppressed EPI (r = -0.57, p = 0.004).”
“Relatively recent … that dexmedetomidine is able to … norepinephrine and epinephrine concentration in approximately 50%, decreases brain blood flow by directly acting on post-synaptic alpha 2 receptors, decreases CSF pressure … suffering and effectively decreases brain metabolism and intracranial pressure and also, able to decrease injury caused by focal ischemia.”
“Relatively recent … that dexmedetomidine is able to … norepinephrine and epinephrine concentration in approximately 50%, decreases brain blood flow by directly acting on post-synaptic alpha 2 receptors, decreases CSF pressure … suffering and effectively decrease brain metabolism and intracranial pressure and also, able to decrease injury caused by focal ischemia.”
“ Dex , imidazoline, yohimbine, and rauwolscine reduced the increases in contraction tension induced by the receptor stimulant adrenaline.”
Effects of dexmedetomidine on porcine pulmonary artery vascular smooth muscle“Moreover, we found that DEX can prolong the local anesthetic duration of lidocaine as much as 1:80,000 epinephrine , up to 35 minutes after injection.”
“Large dose of DEX decreased plasma epinephrine.”
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