Possible Interaction: Epinephrine and Desoxycorticosterone Acetate

“A decrease to 55.8 +/- 7.7% in alpha2-isoform protein was observed 8 days after adrenal removal (P < 0.05); DOCA reversed this effect (90.8 +/- 10.5%).”

“In DOCA hypertensive rats, the depressor responses to intracisternal injections of adrenaline were augmented.”

“An inhibitor of extraneuronal uptake, deoxycorticosterone acetate (DOCA), increased the sensitivities of the rabbit ear artery to extraluminal and to intraluminal epinephrine , each approximately threefold.”

“That the uptake system was readily saturated was suggested by the observation that the sensitising actions of DOCA were decreased by procedures which decreased the potencies of epinephrine and isoprenaline, namely, phentolamine, and doses of isoprenaline eliciting constriction via alpha-stimulation, respectively.”

“A decrease to 55.8 ± 7.7% in α2-isoform protein was observed 8 days after adrenal removal ( P < 0.05); DOCA reversed this effect (90.8 ± 10.5%).”

“Summary Desoxycorticosterone acetate increased the glycogenolytic action of epinephrine in the rectus femoris and abdominal muscles but not in the diaphragm in intact rats.”

“On the other hand, studies in this …, 23) indicate that the administration of DCA to the rat induces a relative state of adrenocortical insufficiency by inhibiting the output of pituitary adrenocorticotropic …) and by antagonizing, at a target-cell level, the action of the ACTH-induced secretion of the adrena...”

“Even the administration of desoxycorticosterone acetate (DCA) or adrenal cortical extracts will only maintain a normal response to hydration for a short period of time (Gaunt, 1944; Gaunt, Liling and Cordsen, 1945; Hays and Mathieson, 1945), although injections of epinephrine will increase the diuresis.”