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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Epinephrine
drug:
Desflurane
Research Papers that Mention the Interaction
“With desflurane, plasma epinephrine and AVP concentrations decreased quickly from their peak values, remaining elevated for 8 min.”
Rapid Increase in Desflurane Concentration Is Associated with Greater Transient Cardiovascular Stimulation Than with Rapid Increase in Isoflurane Concentration in Humans“increases in plasma epinephrine with the second and third increases in desflurane concentration were attenuated.”
“Further electrophysiological studies are needed to determine the exact mechanism of QT shortening in co-administration of adrenaline and desflurane.”
“They concluded that desflurane caused progressive prolongation of the QTc interval, and adrenaline shortened QTc interval at application periods, due to increment in heart rate and ventricular contractility.”
“BackgroundLarge (0.5–1.0 MAC), rapid increases of desflurane to concentrations greater than 5% can transiently increase heart rate, mean arterial blood pressure (MAP), sympathetic nerve activity, and plasma epinephrine concentration.”
“ConclusionsSmall (1%) increases in desflurane concentration to and greater than 6% can transiently increase heart rate, mean arterial pressure, and plasma epinephrine concentration.”
“The 1% increases in desflurane concentration to greater than 5% also transiently increased plasma epinephrine concentrations but not vasopressin concentration or plasma renin activity in those volunteers in whom MAP increased.”
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