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Possible Interaction: Epinephrine and Colforsin

supplement:

Epinephrine

Research Papers that Mention the Interaction

When either isoproterenol or epinephrine (0.1 mM) was combined with forskolin , the magnitude of response was substantially greater than the sum of responses achieved by each agent incubated alone.
Life sciences  •  1982  |  View Paper
In addition to the experiments with reconstituted cyc-, we have demonstrated that forskolin increased the apparent affinity of epinephrine for activation of adenylate cyclase in WT, and reciprocally, epinephrine increased the apparent affinity of forskolin for activation.
Journal of cyclic nucleotide research  •  1982  |  View Paper
In its drug interactions, forskolin may act synergistically with epinephrine , ephedrine and pseudoephedrine.
Journal of postgraduate medicine  •  2012  |  View Paper
Furthermore, the protective effect of epinephrine was mimicked by isoproterenol (1 microM) and forskolin (1 microM) but not by phenylephrine (10 microM) and was blunted by propranolol (10 microM) but not by prazozin (10 microM).
Molecular pharmacology  •  2000  |  View Paper
In alpha 2C-AR transfectants expressing higher receptor densities (650-1,200 fmol/mg), epinephrine inhibited the effect of forskolin by 30 +/- 3.2%.
The Journal of Biological Chemistry  •  1997  |  View Paper
epinephrine (1-100 microM) each reduced peak Kir … +/- 7.0%, respectively, at 100 microM. Forskolin (KD of approximately 25 microM), an activator of adenylate cyclase (AC), and dibutyryl-cyclic AMP (1 mM), … used to increase [cAMP]i, the product of AC, and resulted in similar reductions of Kir currents.
Journal of neurochemistry  •  1995  |  View Paper
Tetraethylammonium (TEA), a blocker of both the Kmaxi and the delayed-rectifier K+ channel, and forskolin attenuated the effect of epinephrine in +/+ but not in the ob/ob beta-cells.
The American journal of physiology  •  1993  |  View Paper
Using 40 nM [3H]-forskolin it was shown that the extent of forskolin binding using a filtration technique increased with the concentration of epinephrine or isoproterenol (INE).
Second messengers and phosphoproteins  •  1988  |  View Paper
Forskolin (1 microM) inhibited responses to EPI and prevented the antagonistic effect of idazoxan, but not that of prazosin.
The Journal of pharmacology and experimental therapeutics  •  1987  |  View Paper
Forskolin in combination with epinephrine caused a decrease in intraocular pressure of longer duration than either 0.1% epinephrine or 1% forskolin administered separately.
The ability of forskolin to potentiate the ocular hypotensive effect of epinephrine was investigated.
Current eye research  •  1987  |  View Paper
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