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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Epinephrine
drug:
Colforsin
Research Papers that Mention the Interaction
“When either isoproterenol or epinephrine (0.1 mM) was combined with forskolin , the magnitude of response was substantially greater than the sum of responses achieved by each agent incubated alone.”
Alpha-2 adrenergic activation inhibits forskolin-stimulated adenylate cyclase activity and lipolysis in human adipocytes.“In addition to the experiments with reconstituted cyc-, we have demonstrated that forskolin increased the apparent affinity of epinephrine for activation of adenylate cyclase in WT, and reciprocally, epinephrine increased the apparent affinity of forskolin for activation.”
Direct evidence for the role of the coupling proteins in forskolin activation of adenylate cyclase.“In its drug interactions, forskolin may act synergistically with epinephrine , ephedrine and pseudoephedrine.”
“Furthermore, the protective effect of epinephrine was mimicked by isoproterenol (1 microM) and forskolin (1 microM) but not by phenylephrine (10 microM) and was blunted by propranolol (10 microM) but not by prazozin (10 microM).”
“In alpha 2C-AR transfectants expressing higher receptor densities (650-1,200 fmol/mg), epinephrine inhibited the effect of forskolin by 30 +/- 3.2%.”
“… epinephrine (1-100 microM) each reduced peak Kir … +/- 7.0%, respectively, at 100 microM. Forskolin (KD of approximately 25 microM), an activator of adenylate cyclase (AC), and dibutyryl-cyclic AMP (1 mM), … used to increase [cAMP]i, the product of AC, and resulted in similar reductions of Kir currents.”
“Tetraethylammonium (TEA), a blocker of both the Kmaxi and the delayed-rectifier K+ channel, and forskolin attenuated the effect of epinephrine in +/+ but not in the ob/ob beta-cells.”
“Using 40 nM [3H]-forskolin it was shown that the extent of forskolin binding using a filtration technique increased with the concentration of epinephrine or isoproterenol (INE).”
“ Forskolin (1 microM) inhibited responses to EPI and prevented the antagonistic effect of idazoxan, but not that of prazosin.”
“ Forskolin in combination with epinephrine caused a decrease in intraocular pressure of longer duration than either 0.1% epinephrine or 1% forskolin administered separately.”
“The ability of forskolin to potentiate the ocular hypotensive effect of epinephrine was investigated.”
The effects of forskolin on cyclic AMP, intraocular pressure and aqueous humor formation in rabbits.
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