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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Epinephrine
drug:
Colforsin
Research Papers that Mention the Interaction
“The 50% inhibiting concentration of adrenaline on forskolin-stimulated cAMP levels was significantly (P<0.01) lower in normotensive (22+/-2 nM) than in hypertensive subjects (200+/-25 nM).”
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension.“In its drug interactions, forskolin may act synergistically with epinephrine , ephedrine and pseudoephedrine.”
“ Forskolin inhibited, in a dose-dependent way, platelet aggregation in response to collagen and adrenaline in platelet-rich plasma.”
“The effect of adrenaline on the whole‐cell current was found to be mimicked by forskolin and could be abolished by including GDP beta S or a protein kinase A inhibitor in the pipette solution.”
“UK-14,304 and epinephrine inhibited forskolin- and vasoactive intestinal peptide-stimulated adenylate cyclase in a dose-dependent manner up to 32%.”
“When either isoproterenol or epinephrine (0.1 mM) was combined with forskolin , the magnitude of response was substantially greater than the sum of responses achieved by each agent incubated alone.”
“The effect of adrenaline was mimicked by forskolin (10 μM) and Br-cAMP (0.5 mM) which caused a fall in pHi by 0.35±0.03 and 0.35±0.02 pH unit respectively.”
Intracellular pH measurement in primary monolayer cultures of rat epididymal cells“ Adrenaline decreased [Ca(2+)](i) in oscillating cells in the presence of low glucose and in cells stimulated by glucose alone or in combination with tolbutamide and forskolin.”
“Furthermore, the protective effect of epinephrine was mimicked by isoproterenol (1 microM) and forskolin (1 microM) but not by phenylephrine (10 microM) and was blunted by propranolol (10 microM) but not by prazozin (10 microM).”
“The effect of adrenaline was mimicked by dibutyryl-cAMP, forskolin , and isobutyl methyl xanthine.”
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