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“The 50% inhibiting concentration of adrenaline on forskolin-stimulated cAMP levels was significantly (P<0.01) lower in normotensive (22+/-2 nM) than in hypertensive subjects (200+/-25 nM).”
“The effect of adrenaline on the whole‐cell current was found to be mimicked by forskolin and could be abolished by including GDP beta S or a protein kinase A inhibitor in the pipette solution.”
“When either isoproterenol or epinephrine (0.1 mM) was combined with forskolin , the magnitude of response was substantially greater than the sum of responses achieved by each agent incubated alone.”
“The effect of adrenaline was mimicked by forskolin (10 μM) and Br-cAMP (0.5 mM) which caused a fall in pHi by 0.35±0.03 and 0.35±0.02 pH unit respectively.”
“ Adrenaline decreased [Ca(2+)](i) in oscillating cells in the presence of low glucose and in cells stimulated by glucose alone or in combination with tolbutamide and forskolin.”
“Furthermore, the protective effect of epinephrine was mimicked by isoproterenol (1 microM) and forskolin (1 microM) but not by phenylephrine (10 microM) and was blunted by propranolol (10 microM) but not by prazozin (10 microM).”