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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Epinephrine
drug:
Carvedilol
Research Papers that Mention the Interaction
“ RESULTS Carvedilol and propranolol inhibited platelet aggregation in the rank order of stimuli: PMA > thrombin > A23187 > epinephrine.”
Carvedilol--a beta-blocker with considerable antiaggregatory effect on human blood platelets.“ Carvedilol can, more effectively than atenolol, inhibit these effects of epinephrine.”
“These effects of epinephrine were completely inhibited by carvedilol.”
“The … of carvedilol decreased, depending on the stimulus used, in the following rank order of potency (in parentheses the respective mean inhibitory concentrations of carvedilol … propranolol are given in micromol/l): PMA (19 and 34) > thrombin (55 and 77) > Ca(2+)-ionophore A23187 (58 and 81) > epinephrine (86 … 118).”
Antiplatelet activity of carvedilol in comparison to propranolol“Because carvedilol is both a nonselective beta- and alpha1-selective adrenergic receptor-blocking agent, we hypothesized that pretreatment with carvedilol would convert the actions of epinephrine to that of a selective alpha2-agonist.”
“ Carvedilol pretreatment followed by epinephrine treatment reduced early postresuscitation ventricular ectopy (116 +/- 147 vs 834 +/- 380, P < .01) and minimized increases in arterial blood lactate at 5 minutes after resuscitation (10.9 +/- 2.1 mmol/L vs 17.4 +/- 3.5 mmol/L, P < .01).”
Carvedilol Mitigates Adverse Effects of Epinephrine During Cardiopulmonary Resuscitation
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