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Last Updated: 2 years ago

Possible Interaction: Epinephrine and Carvedilol

supplement:

Epinephrine

Research Papers that Mention the Interaction

Carvedilol , a nonselective β-adrenergic receptor antagonist, suppressed the facilitating effects of Epi on the Atrogin-1 mRNA induction by LPS, and abolished the effects of Epi on the MHC protein loss in the presence of LPS.
PloS one  •  2021  |  View Paper
The nonselective -adrenergic and 1-adrenergic blocking properties of carvedilol lead to peipheral vasodilation, decreased cardiac epinephrine levels, nd increased parasympathetic none.
Heart rhythm  •  2007  |  View Paper
Chronic carvedilol treatment of patients with non-terminal heart failure reduced the inotropic sensitivity of atrial trabeculae to noradrenaline and adrenaline 5.6-fold and 91.2-fold, respectively, compared to beta1-blocker-treated patients, consistent with persistent preferential blockade of beta2-adrenoceptors.
In terminal heart failure carvedilol treatment reduced 1.8-fold and 25.1-fold the sensitivity of right ventricular trabeculae to noradrenaline and adrenaline , respectively, but metoprolol treatment did not reduce the sensitivity to the catecholamines.
RESULTS Ca vedilol wa s a 13-fold more potent competitive antagonist of the effects of adr enaline at beta2-adrenoceptors (-logKB=10.13+/-0.08) than of noradrenaline at beta1-adrenoceptors (-logKB=9.02+/-0.07) in human right atrium.
Cardiovascular research  •  2006  |  View Paper
Carvedilol can, more effectively than atenolol, inhibit these effects of epinephrine.
These effects of epinephrine were completely inhibited by carvedilol.
Cardiovascular research  •  2000  |  View Paper
Pretreatment of carvedilol orally at a dose of 1 mg/kg body weight for 2 weeks significantly prevented initial reduction in serum electrolyte levels induced by adrenaline.
Bangladesh Medical Research Council bulletin  •  2009  |  View Paper
Because carvedilol is both a nonselective β- and α1-selective adrenergic receptor-blocking agent, we hypothesized that pre-treatment with carvedilol would convert the actions of epinephrine to that of a selective a2-agonist.
Carvedilol pretreatment followed by epinephrine treatment reduced early postresuscitation ventricular ectopy (116 ± 147 vs 834 ± 380, P < .01) and minimized increases in arterial blood lactate at 5 minutes after resuscitation (10.9 ± 2.1 mmol/L vs 17.4 ± 3.5 mmol/L, P < .01).
Journal of cardiovascular pharmacology and therapeutics  •  2005  |  View Paper
The … of carvedilol decreased, depending on the stimulus used, in the following rank order of potency (in parentheses the respective mean inhibitory concentrations of carvedilol … are given in w mol/l): PMA (19 and 34) > thrombin (55 and 77) > Ca 2+ -ionophore A23187 (58 and 81) > epinephrine (86 … 118).
Platelets  •  2002  |  View Paper