Possible Interaction: Epinephrine and Calcium Supplement

“In addition, epinephrine's hyperglycemic effect was blunted by calcium.”

“Aggregation and … ADP and epinephrine … Ca++ at 1--2 mM. The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence … released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release.”

“The substitution resulted in Na(+)-dependent depolarization of adrenal cells and increased intracellular calcium concentration, which activated the transcription of NR4A2 and, in turn, CYP11B2.”

“Activation of α1A by epinephrine in donor cells led to dose-dependent calcium increases in recipient cells, which were detected by measuring the intensity of aequorin luminescence.”

“During microdialysis, epinephrine increased dialysate glycerol concentrations by 250% without and 254% with calcium.”

“Although insulin output was high in the absence of glucose, this was not due to passive leak of hormone, since both removal of calcium and addition of somatostatin and epinephrine inhibited the secretion.”

“Immunofluorescence microscopy showed increased membrane staining of annexin I by calcium , which was inhibited by the addition of epinephrine or hydrocortisone.”

“Clinicians should recognize that in certain circumstances, calcium may interact negatively with catecholamines such as epinephrine or dobutamine.”

“In human erythroleukemia (HEL) cells, both NPY and epinephrine (acting through alpha 2-adrenergic receptors) inhibit adenylate cyclase and mobilize intracellular Ca++.”

“Serum concentrations of calcium , magnesium, potassium and phosphate can be lowered experimentally by adrenaline , which also can stimulate the secretion of parathyroid hormone (PTH).”