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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Bretylium
Research Papers that Mention the Interaction
“Epinephrine may precipitate myocardial ischemia, tachyarrhythmias, hypertensive crisis, pulmonary edema, … toxicity, and cardiac arrest.5 Antidepressants, anesthetics, sympathomimetics, bretylium , and phosphodiesterase … potentiate epinephrine's arrhythmogenic effect.50 Until definitive data are available, our clinical experience suggests that all patients should receive at least one dose of epinephrine 1 mg.”
The Dose of Epinephrine during Cardiopulmonary Resuscitation in Humans: What Should it Be?“ Bretylium caused a dose-related elevation of plasma epinephrine concentration (354% increase at 40 mg/kg).”
“In a separate study, propranolol (10 mg/kg) and bretylium (40 mg/kg) significantly increased epinephrine spillover rate by 85% and 118%, respectively.”
Propranolol and atenolol inhibit norepinephrine spillover rate into plasma in conscious spontaneously hypertensive rats“In the presence of bretylium the effects of adrenaline and noradrenaline were increased, as after sympathectomy.”
“The pressor and depressor effects of adrenaline and the pressor effect of noradrenaline were all enhanced by bretylium.”
[SOME PHARMACOLOGICAL OBSERVATIONS ON BRETYLIUM AND ITS RELATED COMPOUNDS].“ Bretylium and guanethidine blocked the pressor effect of physostigmine and potentiated the responses to adrenaline and noradrenaline on the blood pressure of the rat.”
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