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Last Updated: 3 months ago

Possible Interaction: Epinephrine and Bretylium

supplement:

Epinephrine

Research Papers that Mention the Interaction

Epinephrine may precipitate myocardial ischemia, tachyarrhythmias, hypertensive crisis, pulmonary edema, … toxicity, and cardiac arrest.5 Antidepressants, anesthetics, sympathomimetics, bretylium , and phosphodiesterase … potentiate epinephrine's arrhythmogenic effect.50 Until definitive data are available, our clinical experience suggests that all patients should receive at least one dose of epinephrine 1 mg.
DICP : the annals of pharmacotherapy  •  1991  |  View Paper
Bretylium caused a dose-related elevation of plasma epinephrine concentration (354% increase at 40 mg/kg).
In a separate study, propranolol (10 mg/kg) and bretylium (40 mg/kg) significantly increased epinephrine spillover rate by 85% and 118%, respectively.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
In the presence of bretylium the effects of adrenaline and noradrenaline were increased, as after sympathectomy.
British journal of pharmacology and chemotherapy  •  1959  |  View Paper
The pressor and depressor effects of adrenaline and the pressor effect of noradrenaline were all enhanced by bretylium.
Yao xue xue bao = Acta pharmaceutica Sinica  •  1964  |  View Paper
Bretylium and guanethidine blocked the pressor effect of physostigmine and potentiated the responses to adrenaline and noradrenaline on the blood pressure of the rat.
British journal of pharmacology and chemotherapy  •  1963  |  View Paper